Evidence map›Paper›PMID 39532847›Full record

ArticleNature communications2024

Simultaneous detection of membrane contact dynamics and associated Ca

Paloma García Casas, Michela Rossini, Linnea Påvénius, Mezida Saeed, Nikita Arnst, Sonia Sonda, Tânia Fernandes, Irene D'Arsiè, Matteo Bruzzone, Valeria Berno and 13 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. ATP synthase subunits e and g are essential for CaCell death and differentiation · 2026
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  7. Peroxisome calcium uptake is dependent on ER-peroxisome membrane contact.Cellular and molecular life sciences : CMLS · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Paloma García Casas *Department of Biomedical Sciences, University of Padua, Padua, Italy.
Michela Rossini *Department of Biomedical Sciences, University of Padua, Padua, Italy.ORCID 0009-0008-9482-0371
Linnea PåvéniusScience for Life Laboratory,, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6730-2458
Mezida SaeedScience for Life Laboratory, Department of Applied Physics, Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0003-1921-6015
Nikita ArnstDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Sonia SondaDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Tânia FernandesDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Irene D'ArsièDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Matteo BruzzoneDepartment of Biomedical Sciences, University of Padua, Padua, Italy.ORCID 0000-0001-7683-8107
Valeria BernoALEMBIC, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andrea RaimondiALEMBIC, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-4563-386X
Maria Livia SassanoCell Death Research and Therapy lab, Department of Cellular and Molecular Medicine, and Center for Cancer Biology-VIB, KU Leuven, Leuven, Belgium.ORCID 0000-0002-2262-6915
Luana NaiaDepartment of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-0886-4634
Elisa BarbieriIEO, European Institute of Oncology IRCCS, Milan, Italy.
Sara SigismundIEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID 0000-0002-1396-4453
Patrizia AgostinisCell Death Research and Therapy lab, Department of Cellular and Molecular Medicine, and Center for Cancer Biology-VIB, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1314-2115
Mattia SturleseMolecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.ORCID 0000-0003-3944-0313
Barbara A NiemeyerMolecular Biophysics, Saarland University, Homburg, Germany.ORCID 0000-0002-6963-0575
Hjalmar BrismarScience for Life Laboratory,, Karolinska Institutet, Stockholm, Sweden.
Maria AnkarcronaDepartment of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7022-3694
Arnaud GautierSorbonne Université, École Normale Supérieure, Université PSL, CNRS, Laboratoire des Biomolécules, LBM, 75005, Paris, France.ORCID 0000-0003-1017-9879
Paola PizzoDepartment of Biomedical Sciences, University of Padua, Padua, Italy. paola.pizzo@unipd.it.ORCID 0000-0001-6077-3265
Riccardo FiladiDepartment of Biomedical Sciences, University of Padua, Padua, Italy. riccardo.filadi@cnr.it.ORCID 0000-0002-5871-2620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membrane contact sites (MCSs) are hubs allowing various cell organelles to coordinate their activities. The dynamic nature of these sites and their small size hinder analysis by current imaging techniques. To overcome these limitations, we here design a series of reversible chemogenetic reporters incorporating improved, low-affinity variants of splitFAST, and study the dynamics of different MCSs at high spatiotemporal resolution, both in vitro and in vivo. We demonstrate that these versatile reporters suit different experimental setups well, allowing one to address challenging biological questions. Using these probes, we identify a pathway in which calcium (Ca

Indexed as

Biosensing TechniquesCalciumCalcium SignalingEndoplasmic ReticulumMitochondriaAnimalsCell MembraneHEK293 CellsHeLa CellsHumansCalcium

Identifiers

PMID39532847
PMCPMC11557831

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.