ReviewJournal of perinatology : official journal of the California Perinatal Association2025
ABCs of base therapy in neonatology: role of acetate, bicarbonate, citrate and lactate.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Association of early biochemical markers with in-hospital mortality in infants with neonatal encephalopathy.Pediatric research · 2026Article
- Association between anion gap trajectories and mortality in patients with acute cholangitis: a cohort study.Scientific reports · 2026Article
- Therapeutic strategies for hypertension: exploring the role of microbiota-derived short-chain fatty acids in kidney physiology and development.Pediatric nephrology (Berlin, Germany) · 2026Review
- Balanced fluid bolus: Should we prefer balanced crystalloids over "normal" saline?Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Administration of Sodium Bicarbonate in Critically Ill Newborns: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2026Review
- Fetal dextro-transposition of the great arteries: a narrative review of management and neurodevelopmental outcomes.Frontiers in pharmacology · 2026Review
- Predicting severe intraventricular hemorrhage in very preterm and/or very low birth weight infants: a nomogram approach.Frontiers in pediatrics · 2026Article
- Metabolic acidosis as a risk factor for bronchopulmonary dysplasia in preterm infants born between 23 + 0 and 31 + 6 weeks of gestation: a retrospective case-control study.Frontiers in pediatrics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Metabolic acidosis is common in preterm and term newborn infants and may be attributed to a variety of etiologies, potentially requiring base therapy such as acetate or bicarbonate. However, concerns exist regarding potential harm of sodium bicarbonate due to intracellular acidosis, fluctuations in cerebral blood flow, and osmolar load with rapid infusions, with no improvement in survival when used during resuscitation. Alternative approaches to correct metabolic acidosis include the addition of acetate in parenteral nutrition, intravenous lactated Ringer's (LR) solution, and use of oral citrate. Current guidelines focus on addressing the underlying cause of acidosis, reserving the use of sodium bicarbonate (NaHCO
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.