Evidence map›Paper›PMID 39536059›Full record

ArticleEpigenetics2024

Sex and tissue-specificity of piRNA regulation in adult mice following perinatal lead (Pb) exposure.

Bambarendage P U Perera, Kai Wang, Dongyue Wang, Kathleen Chen, Alisa Dewald, Swati Sriram, Jaclyn M Goodrich, Laurie K Svoboda, Maureen A Sartor, Dana C Dolinoy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bambarendage P U PereraDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-7774-0985
Kai WangDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Palmer Commons, Ann Arbor, MI, USA.
Dongyue WangDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Kathleen ChenDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Alisa DewaldDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Swati SriramDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Jaclyn M GoodrichDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8289-9253
Laurie K SvobodaDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Maureen A SartorDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Palmer Commons, Ann Arbor, MI, USA.
Dana C DolinoyDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3M
Environmental Epigenomics and Precision Environmental HealthR35ES031686 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2020 to 2026
$6.1M
Perinatal Exposures, Tissue- and Cell-specific Epigenomics, & Lifecourse OutcomesU01ES026697 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DOLINOY, DANA · 2016 to 2019
$3.6M
Development of piRNAs for target-specific methylationR01ES026877 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DOLINOY, DANA · 2015 to 2018
$2.2M
Imprinted Gene Regulation by in utero Lead Exposure in MiceK01ES035064 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bambarendage Pinithi Upekka Perera · 2024 to 2026
$462k
Improving chemical exposome target prediction by application of Coupled Matrix/Tensor-Matrix/Tensor Completion algorithmsK99ES034429 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, KAI · 2023 to 2024
$236k
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIEHS NIH HHS K01 ES035064NIEHS NIH HHS K99 ES034429NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES026877NIEHS NIH HHS R35 ES031686NIEHS NIH HHS U01 ES026697
6 · The paper itself

Abstract

Lead (Pb) is a neurotoxicant with early life exposure linked to long-term health effects. Piwi-interacting RNAs (piRNAs) are small non-coding RNAs that associate with PIWIL proteins to induce DNA methylation. It remains unknown whether Pb exposure influences piRNA expression. This study evaluated how perinatal Pb exposure (32 ppm in drinking water) impacts piRNA expression in adult mice and assessed piRNA dysregulation as a potential mechanism for Pb-induced toxicity. Pb exposure effects on piRNA expression and associated gene repression in the germline (testis/ovary) and soma (liver and brain) were evaluated. Small RNA sequencing was used to determine differentially expressed piRNAs, RT-qPCR to examine piRNA target expression, and whole genome bisulfite sequencing to evaluate target DNA methylation status. Three piRNAs (mmpiR-1500602, mmpiR-0201406, and mmpiR-0200026) were significant after multiple testing correction (all downregulated in the male Pb-exposed brain in comparison to control; FDR < 0.05). Within piOxiDB, TAO Kinase 3 was identified as a downstream mRNA target for one of the three Pb-sensitive piRNA. The Pb-exposed male brain exhibited increased

Indexed as

DNA MethylationLeadRNA, Small InterferingAnimalsBrainFemaleLiverMaleMiceMice, Inbred C57BLOrgan SpecificityOvaryPiwi-Interacting RNAPregnancyPrenatal Exposure Delayed EffectsTestisLeadPiwi-Interacting RNARNA, Small InterferingDNA methylationgermlinelead (Pb)ncRNApiRNAsomatic

Identifiers

PMID39536059
PMCPMC11562917

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.