ArticleScientific reports2024
Reducing the effective dose of doxycycline using chitosan silver nanocomposite as a carriers on gram positive and gram-negative bacteria.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Structure-Property Relationships Governing Encapsulation and Release of Antibiotics from Calcium-Alginate Hydrogels.Gels (Basel, Switzerland) · 2026Article
- Network pharmacology and molecular docking reveal antiviral mechanisms of silver nanoparticles synthesized by Oscillatoria sp. against HCV pathogenesis.Scientific reports · 2025Article
- Ag/ZnO nanodots from Artemisia austroyunnanensis as antibacterial and anticancer agents against human neuroblastoma cells.Scientific reports · 2025Article
- Preparation and property evaluation of oral colon targeted protein delivery system with sodium alginate and chitosan.Scientific reports · 2025Article
- PEGylated chitosan xerogels for localized periodontal therapy: design, characterization, and drug release.Scientific reports · 2025Article
- Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems.Beilstein journal of nanotechnology · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Doxycycline (Doxy) is a tetracycline antibiotic with a potent antibacterial activity against a broad range of bacteria. Using nanotechnology is one feasible way to increase the antibiotics' ability to penetrate the body and increase their antibacterial effectiveness. In this work, we report the formation of a stable green synthesized silver nanoparticles (AgNPs) by chitosan with Doxy nanocomposite for the first time. The obtained nanoparticles were characterized by transmission electron microscopy (TEM), zeta-potential, UV-Visible spectroscopy and four transform infrared spectroscopy (FTIRs). The antibacterial effect of doxy, AgNPs and doxy/AgNPs were determined on Gram-positive Staphylococcus aureus, Streptococcus mutans and Gram-negative Escherichia coli, Klebsiella pneumonia. This combined therapeutic agent restored the susceptibility of doxy and showed an antibacterial activity against tested bacteria. AgNPs has absorption peak at 445 nm, mixing of Doxy with AgNPs causes all doxy absorptions to red shift and a broadening in surface plasmon resonance (SPR) for AgNPs and show a slight increase in particle size of AgNPs from 12 ± 2 nm to 14 ± 2 nm with high stability as zeta potential was 29 mv and 48.5mv for AgNPs and Doxy/AgNPs respectively. The antibacterial effect of Doxy/AgNPs nanocomposite was found to be twice effect of free doxy, suggesting a synergistic interaction between the two components. In conclusion, synergy of doxy with AgNPs is quite promising for antibiotic resistant strains. These results highlight the ability of AgNPs to boost the efficacy of the doxycycline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.