Evidence map›Paper›PMID 39538096›Full record

ArticleMolecular imaging and biology2024

Thymidine Phosphorylase Imaging Probe for Differential Diagnosis of Metabolic dysfunction-associated Steatohepatitis.

Kei Higashikawa, Riho Uehara, Sawako Horiguchi, Yuki Shibata, Naoto Okubo, Yuki Mizuno, Hironobu Yasui, Shunsuke Ohnishi, Hiroshi Takeda, Yuji Kuge

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Article in Molecular imaging and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Kei HigashikawaCentral Institute of Isotope Science, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.
Riho UeharaFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Sawako HoriguchiFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Yuki ShibataCentral Institute of Isotope Science, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.
Naoto OkuboFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Yuki MizunoCentral Institute of Isotope Science, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.
Hironobu YasuiCentral Institute of Isotope Science, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.
Shunsuke OhnishiFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Hiroshi TakedaFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Yuji KugeCentral Institute of Isotope Science, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-0815, Japan. kuge@ric.hokudai.ac.jp.ORCID 0000-0002-0483-9706

Funding

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (Grant number: 19K17255)
6 · The paper itself

Abstract

purposeMetabolic dysfunction-associated steatotic liver disease (MASLD) comprises simple steatosis (SS), which has a low risk of mortality, and metabolic dysfunction-associated steatohepatitis (MASH), which can progress to liver cirrhosis and hepatocellular carcinoma. Because differentiation between MASH and SS is the most important issue in the diagnosis of MASLD, the establishment of noninvasive diagnostic methods is urgently needed. In this study, we evaluated the potential of [ PROCEDURES: SS and MASH mice were prepared by feeding db/db mice with a standard diet and a methionine/choline-deficient diet, respectively. Control mice were prepared by feeding m/m mice with a standard diet. TYMP expression in the liver was evaluated by RT-PCR, western blotting, and immunohistochemistry. The biodistribution of [

resultsHepatic TYMP expression level was the highest in the SS mice and the lowest in the MASH mice at both mRNA and protein levels. The immunohistochemistry experiment showed a patchy distribution of TYMP only in the liver of MASH mice. In the biodistribution study, the hepatic accumulation of [

conclusionHepatic TYMP expression level may serve as a promising imaging biomarker for differential diagnosis of SS and MASH. SPECT imaging using [

Indexed as

Fatty LiverThymidine PhosphorylaseAnimalsDiagnosis, DifferentialDisease Models, AnimalLiverMaleMiceMice, Inbred C57BLMolecular ProbesSingle Photon Emission Computed Tomography Computed TomographyTissue DistributionTomography, Emission-Computed, Single-PhotonMolecular ProbesThymidine Phosphorylase5-iodo-6-[(2-iminoimidazolidinyl)methyl]uracil (IIMU)Metabolic dysfunction-associated steatohepatitis (MASH)Non-alcoholic steatohepatitis (SS)Nuclear medicine imagingThymidine phosphorylase (TYMP)

Identifiers

PMID39538096

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.