Evidence map›Paper›PMID 39541080›Full record

ArticleMolecular diagnosis & therapy2025

Selecting Targets for Molecular Imaging of Gastric Cancer: An Immunohistochemical Evaluation.

Ruben D Houvast, Maurice van Duijvenvoorde, Kira Thijse, Wobbe O de Steur, Lioe-Fee de Geus-Oei, A Stijn L P Crobach, Jacobus Burggraaf, Alexander L Vahrmeijer, Peter J K Kuppen

Abstract read
In one paragraph

Article in Molecular diagnosis & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Antibody-drug conjugates in gastric cancer: clinical advances and resistance mechanisms.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Review
  4. Article
  5. Article
  6. Progress in the treatment of duodenal cancer: A comprehensive review.World journal of gastrointestinal oncology · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruben D HouvastDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands. R.D.Houvast@lumc.nl.ORCID 0000-0002-8813-0330
Maurice van DuijvenvoordeDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Kira ThijseDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Wobbe O de SteurDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Lioe-Fee de Geus-OeiDepartment of Radiation Science & Technology, Delft University of Technology, Delft, The Netherlands.
A Stijn L P CrobachDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Jacobus BurggraafDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Alexander L VahrmeijerDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Peter J K KuppenDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTumor-targeted positron emission tomography (PET) and fluorescence-guided surgery (FGS) could address current challenges in pre- and intraoperative imaging of gastric cancer. Adequate selection of molecular imaging targets remains crucial for successful tumor visualization. This study evaluated the potential of integrin α

methodsExpression of α

resultsPositive biomarker expression in primary gastric tumors was observed in 86% for α

conclusionOur findings show that CEACAM5, EGFR and EpCAM are promising targets for molecular imaging of primary gastric cancer, as well as visualization of both lymph node and distant metastases. Further clinical evaluation of PET and FGS tracers targeting these antigens is warranted.

Indexed as

Molecular ImagingStomach NeoplasmsAgedBiomarkers, TumorCarcinoembryonic AntigenEpithelial Cell Adhesion MoleculeErb-b2 Receptor Tyrosine KinasesErbB ReceptorsFemaleGPI-Linked ProteinsHumansImmunohistochemistryLymphatic MetastasisMaleMiddle AgedBiomarkers, TumorCarcinoembryonic AntigenCEACAM5 protein, humanEpithelial Cell Adhesion MoleculeERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesErbB ReceptorsGPI-Linked Proteins

Identifiers

PMID39541080
PMCPMC11860997

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.