Evidence map›Paper›PMID 39541706›Full record

ArticleMedical image analysis2025

Large-scale multi-center CT and MRI segmentation of pancreas with deep learning.

Zheyuan Zhang, Elif Keles, Gorkem Durak, Yavuz Taktak, Onkar Susladkar, Vandan Gorade, Debesh Jha, Asli C Ormeci, Alpay Medetalibeyoglu, Lanhong Yao and 28 more

Abstract readMulticenter Study
In one paragraph

Article in Medical image analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Artificial intelligence in pancreatic cancer: applications in early detection, tumor staging, and survival prediction-a comprehensive review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  18. Pediatric pancreas segmentation from MRI scans with deep learning.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors.

Zheyuan ZhangMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Elif KelesMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Gorkem DurakMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Yavuz TaktakDepartment of Internal Medicine, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Onkar SusladkarMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Vandan GoradeMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Debesh JhaMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Asli C OrmeciDepartment of Internal Medicine, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Alpay MedetalibeyogluMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA; Department of Internal Medicine, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Lanhong YaoMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Bin WangMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Ilkin Sevgi IslerMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA; Department of Computer Science, University of Central Florida, Florida, FL, USA.
Linkai PengMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Hongyi PanMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Camila Lopes VendramiMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Amir BourhaniMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Yury VelichkoMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Boqing GongGoogle Research, Seattle, WA, USA.
Concetto SpampinatoUniversity of Catania, Catania, Italy.
Ayis PyrrosDepartment of Radiology, Duly Health and Care and Department of Biomedical and Health Information Sciences, University of Illinois Chicago, Chicago, IL, USA.
Pallavi TiwariDept of Biomedical Engineering, University of Wisconsin-Madison, WI, USA.
Derk C F KlatteDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Netherlands; Department of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Megan EngelsDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Netherlands; Department of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Sanne HoogenboomDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Netherlands; Department of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Candice W BolanDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Emil AgarunovDivision of Gastroenterology and Hepatology, New York University, NY, USA.
Nassier HarfouchDepartment of Radiology, NYU Grossman School of Medicine, New York, NY, USA.
Chenchan HuangDepartment of Radiology, NYU Grossman School of Medicine, New York, NY, USA.
Marco J BrunoDepartments of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands.
Ivo SchootsDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
Rajesh N KeswaniDepartments of Gastroenterology and Hepatology, Northwestern University, IL, USA.
Frank H MillerMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA.
Tamas GondaDivision of Gastroenterology and Hepatology, New York University, NY, USA.
Cemal YaziciDivision of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, IL, USA.
Temel TirkesDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Baris TurkbeyMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Michael B WallaceDivision of Gastroenterology and Hepatology, Mayo Clinic in Florida, Jacksonville, USA.
Ulas BagciMachine & Hybrid Intelligence Lab, Department of Radiology, Northwestern University, Chicago, USA. Electronic address: ulasbagci@gmail.com.

Funding

Data Coordinating Center for the Type 1 Diabetes in Acute Pancreatitis ConsortiumU01DK127384 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Vernon M Chinchilli, Temel Tirkes · 2020 to 2026
$21.3M
Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research NetworkU01DK108323 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jeffrey James Easler, Evan L Fogel · 2015 to 2026
$6.5M
Predicting Pancreatic Ductal Adenocarcinoma PDAC Through Artificial Intelligence Analysis of Pre Diagnostic CT Images in African AmericansR01CA260955 · NCI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO, PANDOL, STEPHEN J. · 2021 to 2025
$4.8M
Cyst-X: Interpretable Deep Learning Based Risk Stratification of Pancreatic Cystic TumorsR01CA246704 · NCI · UNIVERSITY OF CENTRAL FLORIDA · PI BAGCI, ULAS · 2020 to 2024
$2.4M
Indiana University clinical Center for acute pancreatitis and diabetes clinical research networkU01DK127382 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina, Evan L Fogel · 2020 to 2026
$2.4M
Radiologist-Centered Artificial Intelligence (RCAI) for Lung Cancer Screening and DiagnosisR01CA240639 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BAGCI, ULAS · 2020 to 2024
$2.0M
Hybrid Intelligence for Trustable Diagnosis And Patient Management of Prostate Cancer (HIT-PIRADS)U01CA268808 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ulas Bagci · 2023 to 2026
$1.5M
NCI NIH HHS R01 CA240639NCI NIH HHS R01 CA246704NCI NIH HHS R01 CA260955NCI NIH HHS U01 CA268808NIDDK NIH HHS U01 DK108323NIDDK NIH HHS U01 DK127382NIDDK NIH HHS U01 DK127384
6 · The paper itself

Abstract

Automated volumetric segmentation of the pancreas on cross-sectional imaging is needed for diagnosis and follow-up of pancreatic diseases. While CT-based pancreatic segmentation is more established, MRI-based segmentation methods are understudied, largely due to a lack of publicly available datasets, benchmarking research efforts, and domain-specific deep learning methods. In this retrospective study, we collected a large dataset (767 scans from 499 participants) of T1-weighted (T1 W) and T2-weighted (T2 W) abdominal MRI series from five centers between March 2004 and November 2022. We also collected CT scans of 1,350 patients from publicly available sources for benchmarking purposes. We introduced a new pancreas segmentation method, called PanSegNet, combining the strengths of nnUNet and a Transformer network with a new linear attention module enabling volumetric computation. We tested PanSegNet's accuracy in cross-modality (a total of 2,117 scans) and cross-center settings with Dice and Hausdorff distance (HD95) evaluation metrics. We used Cohen's kappa statistics for intra and inter-rater agreement evaluation and paired t-tests for volume and Dice comparisons, respectively. For segmentation accuracy, we achieved Dice coefficients of 88.3% (±7.2%, at case level) with CT, 85.0% (±7.9%) with T1 W MRI, and 86.3% (±6.4%) with T2 W MRI. There was a high correlation for pancreas volume prediction with R

Indexed as

Deep LearningMagnetic Resonance ImagingTomography, X-Ray ComputedDatasets as TopicHumansPancreasPancreatic DiseasesRetrospective StudiesCT pancreasGeneralized segmentationMRI pancreasPancreas segmentationTransformer segmentation

Identifiers

PMID39541706
PMCPMC11698238

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.