Evidence map›Paper›PMID 39542413›Full record

ArticleProgress in neurobiology2024

Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics.

Haichang Luo, Allison Anderson, Ikuo Masuho, Ezequiel Marron Fernandez de Velasco, Lutz Birnbaumer, Kirill A Martemyanov, Kevin Wickman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haichang LuoDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, United States.
Allison AndersonDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, United States.
Ikuo MasuhoDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, United States.
Ezequiel Marron Fernandez de VelascoDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, United States.
Lutz BirnbaumerSignal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States; Biomedical Research Institute, Catholic University of Argentina, Buenos Aires C1107AAZ, Argentina.
Kirill A MartemyanovDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, United States.
Kevin WickmanDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: wickm002@umn.edu.

Funding

Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI TIMOTHY J EBNER · 2020 to 2026
$19.0M
Regulation of Striatal Signaling by RGS ProteinsR01DA036596 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kirill A. Martemyanov · 2014 to 2026
$6.5M
Transmembrane Signaling MechanismsZ01ES101643 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$5.1M
Architecture of inhibitory G protein signaling in the hippocampusR01NS128039 · NINDS · UNIVERSITY OF MINNESOTA · PI Kirill A. Martemyanov, KEVIN D WICKMAN · 2023 to 2026
$2.6M
Targeting the parasympathetic regulation of the heart to treat arrhythmiasF31HL139090 · NHLBI · UNIVERSITY OF MINNESOTA · PI ANDERSON, ALLISON DIANE · 2017 to 2019
$120k
Intramural NIH HHS Z01 ES101643NHLBI NIH HHS F31 HL139090NIDA NIH HHS P30 DA048742NIDA NIH HHS R01 DA036596NINDS NIH HHS R01 NS128039
6 · The paper itself

Abstract

Most neurons are influenced by multiple neuromodulatory inputs that converge on common effectors. Mechanisms that route these signals are key to selective neuromodulation but are poorly understood. G protein-gated inwardly rectifying K

Indexed as

G Protein-Coupled Inwardly-Rectifying Potassium ChannelsHippocampusNeuronsRGS ProteinsSignal TransductionAnimalsMiceReceptor, Adenosine A1Receptor, Serotonin, 5-HT1AReceptors, GABA-BG Protein-Coupled Inwardly-Rectifying Potassium ChannelsReceptor, Adenosine A1Receptor, Serotonin, 5-HT1AReceptors, GABA-BRgs6 protein, mouseRgs7 protein, mouseRGS ProteinsGIRK channelG proteinG protein-coupled receptorHippocampal neuronKir3Regulator of G protein signaling

Identifiers

PMID39542413
PMCPMC11923652

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.