Evidence map›Paper›PMID 39543011›Full record

ArticleTranslational stroke research2025

Targeted TGF-βR2 Silencing in the Retrotrapezoid Nucleus Mitigates Respiratory Dysfunction and Cognitive Decline in a Mouse Model of Cerebral Amyloid Angiopathy with and without Stroke.

Ahmad El Hamamy, Zahid Iqbal, Ngoc Mai Le, Arya Ranjan, YuXing Zhang, Hung Wen Lin, Chunfeng Tan, Destiny Sumani, Anthony Patrizz, Louise D McCullough and 1 more

Abstract read
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In one paragraph

Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ahmad El HamamyDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Zahid IqbalDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Ngoc Mai LeDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Arya RanjanDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
YuXing ZhangDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Hung Wen LinDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Chunfeng TanDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Destiny SumaniDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Anthony PatrizzDepartment of Neurological Surgery and Brain Repair, University of South Florida at Tampa, Tampa, FL, USA.
Louise D McCulloughDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jun LiDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. jun.li.3@uth.tmc.edu.

Funding

Stroke Disordered Breathing and its Impact on Cognitive Decline in Aging, Alzheimer's Disease and Cerebral Amyloid AngiopathyRF1AG069466 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LI, JUN, MCCULLOUGH, LOUISE D. · 2020 to 2020
$4.1M
NIH HHS 1RF1AG069466-01A1
6 · The paper itself

Abstract

Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid-beta peptides within cerebral blood vessels, leading to neurovascular complications. Ischemic strokes result from acute disruptions in cerebral blood flow, triggering metabolic disturbances and neurodegeneration. Both conditions often co-occur and are associated with respiratory dysfunctions. The retrotrapezoid nucleus (RTN), which is crucial for CO

Indexed as

Cerebral Amyloid AngiopathyCognitive DysfunctionReceptor, Transforming Growth Factor-beta Type IIRespiration DisordersStrokeAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, TransgenicReceptor, Transforming Growth Factor-beta Type IITgfbr2 protein, mouseCAACognitive impairmentRespiratory dysfunctionRTNStrokeTGF-β signaling

Identifiers

PMID39543011

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.