ReviewNature reviews. Urology2025
Disruption of circadian rhythm as a potential pathogenesis of nocturia.
Review in Nature reviews. Urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Relative circadian disruption in urinary excretion associates with renal function in biopsy-proven primary glomerular diseases: a cross-sectional study using the novel CRDI metric.Renal failure · 2026Article
- A retrospective cross-sectional study on the nonlinear association between cardiovascular health and overactive bladder in a national population-based cohort.Annals of medicine and surgery (2012) · 2026Article
- Genetic and biological mechanisms of pediatric enuresis: integrating pathophysiology, GWAS associations, and multi-omics research.European journal of pediatrics · 2026Review
- Obstructive Sleep Apnea Syndrome and Overactive Bladder: Expanding the Perspective to Women-A Narrative Review.Current urology reports · 2026Review
- Dihydroergotamine alleviates circadian rhythm disorders through predicted interaction with to CRY1.Molecular diversity · 2026Article
- BMAL1 regulates circadian rhythms via phase separation-mediated transcriptional hub formation.Signal transduction and targeted therapy · 2026Article
- Association between light exposure and sleep problems related to nocturia in older adults: the Nagahama study.Journal of physiological anthropology · 2026Article
- Sleep disturbance and risk of incident incontinence in middle-aged and older Chinese adults: a 4-year national cohort study.BMJ open · 2026Article
- Overactive bladder phenotype induced by chronic activation of hypothalamic neuroendocrine stress pathways in rats with no extrinsic behavioral stress applied.Scientific reports · 2025Article
- Diurnal regulation of urinary behavior and gene expression in aged mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- A clinical grade neurostimulation implant for hierarchical control of physiological activity.bioRxiv : the preprint server for biology · 2025Article
- Circadian Lighting Was Associated with a Reduction in the Number of Hospitalized Patients Experiencing Falls: A Retrospective Observational Study.Healthcare (Basel, Switzerland) · 2025Article
- Association between nocturia and sleep issues, incorporating the impact of lifestyle habits perceived as promoting sleep in an internet survey.Scientific reports · 2025Article
- The disruption of circadian rhythm as a potential mechanism of nocturia-like symptoms - a paediatric urology perspective.Nature reviews. Urology · 2025Article
- Reply to 'The disruption of circadian rhythm as a potential mechanism of nocturia-like symptoms - a paediatric urology perspective'.Nature reviews. Urology · 2025Article
- Circadian clocks and their role in kidney and eye diseases across organ systems.Frontiers in physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Increasing evidence suggested the multifactorial nature of nocturia, but the true pathogenesis of this condition still remains to be elucidated. Contemporary clinical medications are mostly symptom based, aimed at either reducing nocturnal urine volume or targeting autonomic receptors within the bladder to facilitate urine storage. The day-night switch of the micturition pattern is controlled by circadian clocks located both in the central nervous system and in the peripheral organs. Arousal threshold and secretion of melatonin and vasopressin increase at night-time to achieve high-quality sleep and minimize nocturnal urine production. In response to the increased vasopressin, the kidney reduces the glomerular filtration rate and facilitates the reabsorption of water. Synchronously, in the bladder, circadian oscillation of crucial molecules occurs to reduce afferent sensory input and maintain sufficient bladder capacity during the night sleep period. Thus, nocturia might occur as a result of desynchronization in one or more of these circadian regulatory mechanisms. Disrupted rhythmicity of the central nervous system, kidney and bladder (known as the brain-kidney-bladder circadian axis) contributes to the pathogenesis of nocturia. Novel insights into the chronobiological nature of nocturia will be crucial to promote a revolutionary shift towards effective therapeutics targeting the realignment of the circadian rhythm.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.