ReviewCureus2024
Osteoarthritis and Neurological Disorder Diagnoses in Adults: A Meta-Analysis Examining Associations With Parkinson's Disease, Multiple Sclerosis, and Alzheimer's Disease.
Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Methylation of PRDX3 Expression Alleviate Ferroptosis and Oxidative Stress in Patients with Osteoarthritis Cartilage Injury.Archives of rheumatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Osteoarthritis (OA) is a highly prevalent joint disorder that is emerging as a global threat to health. OA is associated with low-grade chronic systemic inflammation that can affect overall health, leading to a sedentary lifestyle and potentially increased risk of neurological disorders (ND) such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). A meta-analysis was conducted following the Preferred Reporting Items for 2020 Systematic Reviews and Meta-Analyses (PRISMA) guidelines. MEDLINE, Web of Science, and Embase databases were searched to identify records. The inclusion criteria for this analysis were original research articles reporting on OA and neurological disorder diagnoses (AD, PD, or MS) with non-OA comparator groups. Logarithmic odds ratios (LORs) were calculated and input into a random-effects meta-analysis using the restricted maximum-likelihood estimator. Subgroup analyses examined the associations between OA, AD, PD, and MS. A subsequent meta-regression analysis was performed to explore potential sources of heterogeneity, focusing on comorbidities and demographic factors. Publication bias was evaluated using funnel plots, Egger's test, and trim-and-fill analysis. Nine studies were included in this meta-analysis (six case-control designs, two cross-sectional designs, and one population-based cohort design) of 1,837,716 cases. The pooled odds ratio (OR) indicated a significant association between OA and ND diagnosis (OR = 1.246; confidence interval (CI): 1.01-1.53). Subsequent subgroup analyses were not statistically significant but indicated an association with PD (OR = 1.31, CI: 0.80-2.12), MS (OR = 1.12, CI: 0.80-2.81), and AD (OR = 1.50, CI: 0.80-2.81). This meta-analysis revealed that individuals with OA have approximately 25% higher odds of an accompanying ND diagnosis compared to those without OA. Importantly, these findings represent statistical associations only and do not imply causation or directionality but provide insight into factors, including shared risk factors, overlapping symptoms, or other underlying mechanisms that may influence the observed relationships.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.