Evidence map›Paper›PMID 39548262›Full record

ArticleCommunications biology2024

Age-dependent cerebral vasodilation induced by volatile anesthetics is mediated by NG2

Hang Zhou, Viola Neudecker, Jose F Perez-Zoghbi, Ansgar M Brambrink, Guang Yang

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hang Zhou *Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, 100032, USA.ORCID 0000-0001-8662-9376
Viola Neudecker *Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, 100032, USA.
Jose F Perez-Zoghbi *Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, 100032, USA.
Ansgar M BrambrinkDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, NY, 100032, USA. amb2457@cumc.columbia.edu.ORCID 0000-0003-1299-9432
Guang YangDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, NY, 100032, USA. gy2268@cumc.columbia.edu.ORCID 0000-0002-5739-9126

Funding

Pathogenesis of Postoperative Cognitive DysfunctionR01AG041274 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhongcong Xie, Guang Yang · 2012 to 2026
$6.7M
Pericyte function in anesthetic-induced vasodilation and developmental neurotoxicityR21HD111955 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRAMBRINK, ANSGAR M, YANG, GUANG · 2023 to 2023
$452k
NIA NIH HHS R01 AG041274NICHD NIH HHS R21 HD111955
6 · The paper itself

Abstract

Anesthesia can influence cerebral blood flow by altering vessel diameter. Using in vivo two-photon imaging, we examined the effects of volatile anesthetics, sevoflurane and isoflurane, on vessel diameter in young and adult mice. Our results show that these anesthetics induce robust dilation of cortical arterioles and arteriole-proximate capillaries in adult mice, with milder effects in juveniles and no dilation in infants. This anesthesia-induced vasodilation correlates with decreased cytosolic Ca

Indexed as

Anesthetics, InhalationVasodilationAge FactorsAnimalsArteriolesBrainCerebrovascular CirculationFemaleIsofluraneKATP ChannelsMaleMiceMice, Inbred C57BLSevofluraneAnesthetics, InhalationIsofluraneKATP ChannelsSevoflurane

Identifiers

PMID39548262
PMCPMC11568297

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.