Evidence mapPaperPMID 39548264Full record

ArticleScientific reports2024

Contribution of glucose and glutamine to hypoxia-induced lipid synthesis decreases, while contribution of acetate increases, during 3T3-L1 differentiation.

Lucie Ryskova, Katerina Pospisilova, Jiri Vavra, Tomas Wolf, Ales Dvorak, Libor Vitek, Jan Polak

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucie RyskovaDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Ruska 87, Prague, 100 00, Czech Republic.
Katerina PospisilovaInstitute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Jiri VavraDepartment of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.
Tomas WolfDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Ruska 87, Prague, 100 00, Czech Republic.
Ales DvorakInstitute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Libor VitekInstitute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Jan PolakDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Ruska 87, Prague, 100 00, Czech Republic. jan.polak@lf3.cuni.cz.

Funding

Grant Agency of Charles University GAUK 294822Ministry of Health of the Czech Republic project AZV NU21-01-00259Ministry of Health of the Czech Republic project MH CZ-DRO-VFN64165
6 · The paper itself

Abstract

The molecular mechanisms linking obstructive sleep apnea syndrome (OSA) to obesity and the development of metabolic diseases are still poorly understood. The role of hypoxia (a characteristic feature of OSA) in excessive fat accumulation has been proposed. The present study investigated the possible effects of hypoxia (4% oxygen) on de novo lipogenesis by tracking the major carbon sources in differentiating 3T3-L1 adipocytes. Gas-permeable cultuware was employed to cultivate 3T3-L1 adipocytes in hypoxia (4%) for 7 or 14 days of differentiation. We investigated the contribution of glutamine, glucose or acetate using

Indexed as

3T3-L1 CellsAcetatesAdipocytesCell DifferentiationGlucoseGlutamineLipogenesisAnimalsCell HypoxiaCitric Acid CycleLipid MetabolismLipidsMiceAcetatesGlucoseGlutamineLipids

Identifiers

PMID39548264
PMCPMC11568125

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.