ReviewTrends in immunology2024
Neuroimmune interactions in the olfactory epithelium: maintaining a sensory organ at an immune barrier interface.
Review in Trends in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation.Cell proliferation · 2026Article
- Effects of acute intranasal allergen exposure on resident immune cells and sensory neurons in the mouse olfactory epithelium.bioRxiv : the preprint server for biology · 2026Article
- Transcriptional regulation of the main olfactory epithelium by environmental olfactory exposures.bioRxiv : the preprint server for biology · 2026Article
- Olfactory cleft biopsy analysis of Alzheimer's disease pathobiology across disease stages.Nature communications · 2026Article
- Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19.Frontiers in immunology · 2026Article
- The alarmin-ILC2 axis as a candidate mechanism for persistent olfactory dysfunction in allergic rhinitis.Frontiers in immunology · 2026Article
- Analysis of mucosal immune dysregulation and safety and tolerability of endoscopic topical steroid therapy for long-COVID hyposmia: randomized, double-blinded pilot study.Communications medicine · 2025Article
- Viral destruction of the olfactory mucosa elicits immune residence, bone metaplasia, and long-term smell loss.Mucosal immunology · 2025Article
- Olfactory biopsy analysis of Alzheimer's pathobiology across disease stages.bioRxiv : the preprint server for biology · 2025Article
- Influenza virus-like particles presentingNanomedicine (London, England) · 2025Article
- Omicron Impacts Olfaction in Hamsters.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Organoid models for chemosensing cell studies.American journal of physiology. Cell physiology · 2025Review
- Airway sensory systems: breathing new life into microbiota-brain communication.Frontiers in cellular neuroscience · 2025Review
- Candidate Genetic Markers of Schizophrenia Based on Exome Sequencing Data and Its Relation to Immunological, Clinical, and Morphometric Changes in the Russian Population.Sovremennye tekhnologii v meditsine · 2025Article
- IL-6 and Olfactory Dysfunction: Focus on Changes, Effects, and Mechanisms.Mediators of inflammation · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
While primarily a sensory organ, the mammalian olfactory epithelium (OE) also plays a critical role as an immune barrier. Mechanisms governing interactions between the immune system and this specialized chemosensory tissue are gaining interest, in part sparked by the COVID-19 pandemic. Regulated inflammation is intrinsic to normal mucosal healing and homeostasis, but prolonged OE inflammation is associated with persistent loss of smell, belying the intertwining of local mucosal immunology and olfactory function. Evidence supports bidirectional communication between OE cells and the immune system in health and disease. Recent investigations suggest that neuro-immune cross-talk modulates olfactory stem cell behavior and neuronal regeneration dynamics, prioritizing the epithelial-like non-neuronal framework with immune barrier function at the expense of the neurosensory organ in chronic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.