Evidence map›Paper›PMID 39550568›Full record

SynthesisBMC gastroenterology2024

Impact of perioperative immunonutrition on postoperative outcomes in pancreaticoduodenectomy: a systematic review and meta-analysis of randomized controlled trials.

Gaofeng Zhang, Bing Zhao, Tengang Deng, Xiaofei He, Yongpin Chen, Changtao Zhong, Jie Chen

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07395635 (Impact of Immunonutrition in Patients Undergoing Hepatectomies for Liver Tumors), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07395635 narecruitingnot on this mapstarted 2025, after this paper: background citation

Impact of Immunonutrition in Patients Undergoing Hepatectomies for Liver Tumors: A Randomized Controlled Phase II Trial

TypeinterventionalSponsorTata Memorial CentreRan2025 to 2028Enrolled100ConditionsHepatocellular Carcinoma, ASA I-III PatientsArmsImmunonutrition
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gaofeng ZhangDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Ziliujing District, Zigong, 643000, Sichuan Province, China.
Bing ZhaoDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Ziliujing District, Zigong, 643000, Sichuan Province, China.
Tengang DengDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Ziliujing District, Zigong, 643000, Sichuan Province, China.
Xiaofei HeDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Ziliujing District, Zigong, 643000, Sichuan Province, China.
Yongpin ChenDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Ziliujing District, Zigong, 643000, Sichuan Province, China.
Changtao ZhongDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Ziliujing District, Zigong, 643000, Sichuan Province, China.
Jie ChenDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Ziliujing District, Zigong, 643000, Sichuan Province, China. chenjiezgsdsrmyy@outlook.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis systematic review and meta-analysis aimed to evaluate the impact of perioperative immunonutrition on postoperative outcomes in patients undergoing pancreaticoduodenectomy (PD).

methodsConducted a comprehensive search in PubMed, Embase, Cochrane Library, Medline, and Web of Science databases to identify all randomized controlled trials (RCTs) on the topic of immunonutrition and PD. Subsequently screened literature, extracted data, and assessed the risk of bias in the included studies, and finally conducted a meta-analysis using RevMan 5.3 software.

resultsThe analysis included a total of 10 RCTs with 574 patients, among whom 288 were in the immunonutrition group and 283 in the control group. The meta-analysis revealed a significantly lower incidence of postoperative infection-related complications (OR = 0.45; 95% CI: 0.27-0.74; P = 0.002) and severe postoperative complications (OR = 0.61; 95% CI: 0.38-0.98; P = 0.04) in the immunonutrition group compared to the control group. Additionally, patients in the immunonutrition group had a significantly shorter length of hospital stay (MD= -1.87; 95%CI -3.29 - -0.44; P = 0.01). However, the analysis revealed no statistically significant difference in the overall complication rate between the two groups (P = 0.67). Furthermore, the incidence of specific complications and perioperative mortality rates also did not demonstrate any statistically significant differences (all P > 0.05).

conclusionsPerioperative immunonutrition in PD patients can reduce postoperative infection-related complications, but more high-quality RCTs are needed for further validation.

Indexed as

Length of StayPancreaticoduodenectomyPerioperative CarePostoperative ComplicationsRandomized Controlled Trials as TopicHumansImmunonutrition DietImmunonutritionMeta-analysisPancreaticoduodenectomyPrognosis

Identifiers

PMID39550568
PMCPMC11569618

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.