Evidence map›Paper›PMID 39550581›Full record

ReviewJournal of translational medicine2024

Towards precision medicine: design considerations for nanozymes in tumor treatment.

Xinqiao Li, Jinpeng Hu, Qi Zhao, Weifeng Yao, Zhitao Jing, Zhizhong Jin

Abstract readReview
In one paragraph

Review in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinqiao Li *Department of Neurosurgery, The First Hospital of China Medical University, Nanjing Street 155, Heping district, Shenyang, 110001, People's Republic of China.
Jinpeng Hu *Department of Neurosurgery, The First Hospital of China Medical University, Nanjing Street 155, Heping district, Shenyang, 110001, People's Republic of China.
Qi ZhaoDepartment of Chemistry and the Institute for Sustainability and Energy, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA. qi.zhao1@northwestern.edu.
Weifeng YaoShanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, College of Environmental & Chemical Engineering, Shanghai University of Electric Power, Shanghai, People's Republic of China. yaoweifeng@shiep.edu.cn.
Zhitao JingDepartment of Neurosurgery, The First Hospital of China Medical University, Nanjing Street 155, Heping district, Shenyang, 110001, People's Republic of China. jingzhitao@hotmail.com.ORCID 0000-0002-8915-9039
Zhizhong JinDepartment of Neurosurgery, The First Hospital of China Medical University, Nanjing Street 155, Heping district, Shenyang, 110001, People's Republic of China. zhizhongjin0311@outlook.com.

Funding

National Natural Science Foundation of China No. 82072794
6 · The paper itself

Abstract

Since the discovery of Fe3O4 nanoparticles with enzyme-like activity in 2007, nanozymes have emerged as a promising class of catalysts, offering advantages such as high catalytic efficiency, low cost, mild reaction conditions, and excellent stability. These properties make nanozymes highly suitable for large-scale production. In recent years, the convergence of nanomedicine and nanocatalysis has highlighted the potential of nanozymes in diagnostic and therapeutic applications, particularly in tumor therapy. Despite these advancements, the clinical translation of nanozymes remains hindered by the lack of designs tailored to specific tumor characteristics, limiting their effectiveness in targeted therapy. This review addresses the mechanisms by which nanozymes induce cell death in various tumor types and emphasizes the key design considerations needed to enhance their therapeutic potential. By identifying the challenges and opportunities in the field, this study aims to provide a foundation for future nanozyme development, ultimately contributing to more precise and effective cancer treatments.

Indexed as

NeoplasmsPrecision MedicineAnimalsDrug DesignEnzymesHumansNanoparticlesEnzymesCancer therapyClassificationNanozymeTumor

Identifiers

PMID39550581
PMCPMC11568558

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.