ArticleScientific reports2024
U-shaped association between HbA1c and all-cause mortality in CVD patients with diabetes.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- eHealth Literacy, self-management, and selected clinical and social correlates of nutrition-inflammation level among older adults with diabetes.BMC health services research · 2026Article
- Impact of early and tight HbA1c control on the risk of long-term complications and cardiovascular death in patients with type 2 diabetes from the Swedish National Diabetes Register.Diabetes, obesity & metabolism · 2026Article
- Glycemic control and renal function decline in patients with chronic coronary syndrome: A multicenter cohort study.Journal of diabetes investigation · 2026Observational
- Glycemic control in the context of frailty: a mortality risk assessment in older diabetic patients.Aging clinical and experimental research · 2026Article
- Redox-Responsive Tellurium-Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Association between hemoglobin glycation index and cognitive function: Evidence in the elderly.PloS one · 2026Article
- Calcium dysregulation in diabetic cardiomyopathy & heart failure with preserved ejection fraction.Frontiers in cardiovascular medicine · 2026Review
- Development and validation of a prediction model for urinary tract infection in older patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- Prognostic significance and temporal patterns of glycemic variability in critically ill non-diabetic patients with ischemic stroke: a retrospective multicenter cohort study.Frontiers in neurology · 2026Article
- Comment on "Diabetes mellitus is linked to higher mortality in alcohol‑related acute‑on‑chronic liver failure".Hepatology international · 2025Article
- Interplay of glycated hemoglobin and traditional risk factors for the risk of atherosclerotic cardiovascular disease and all-cause mortality in people without diabetes.Cardiovascular diabetology · 2025Observational
- Undiagnosed Insulinoma in a Young Patient With Idiopathic Dilated Cardiomyopathy: A Case Report.Cureus · 2025Article
- Association between heavy metals and risk of cardiovascular diseases in US adults with prediabetes from NHANES 2011-2018.BMC public health · 2025Article
- Insulin resistance assessed by estimated glucose disposal rate is associated with all-cause and cardiovascular mortality among postmenopausal women.Frontiers in endocrinology · 2025Article
- Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes.Frontiers in endocrinology · 2025Review
- HbA1c as an Independent Predictor of Peripheral Artery Disease: Nonlinear Threshold and Causal Evidence from NHANES and Mendelian Randomization.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisObservational
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3 authors.
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Abstract
In this analysis, the association of baseline glycated hemoglobin (HbA1c) levels with all-cause mortality in cardiovascular disease (CVD) patients with diabetes was investigated using data from NHANES 1999-2014. Under examination were 845 CVD patients who had diabetes and were followed for a median follow-up of 7.3 years, and an all-cause mortality rate of 22.60% was observed. To examine the association between HbA1c and mortality, multivariable Cox proportional hazard models using spline models determined the non-linear association. HbA1c as a continuous variable was not associated with mortality. However, a significant association was observed when HbA1c was classified according to quartiles. Particularly, after adjustment for potential confounders, in comparison to participants with HbA1c levels below 6.2%, patients with HbA1c levels of 6.2-6.8% and 6.9-7.6% had lower risks of all-cause mortality (hazard ratio: 0.49, 95% CI: 0.30-0.80 and hazard ratio: 0.64, 95% CI: 0.39-1.03, respectively). Using restricted cubic splines, further testing confirmed the lack of a linear association and instead suggested a U-shaped relationship between HbA1c and mortality, with an optimal HbA1c target value of 6.9%. A 1-unit increase in HbA1c with HbA1c less than or equal to 6.9% was predictive of a 55% reduction in all-cause mortality compared to HbA1c levels above 6.9%, which exhibited an elevation in risk. All told, these data suggest that the relationship between HbA1c and all-cause mortality in CVD patients with diabetes is non-linear and U-shaped, and therefore may suggest that individualization of glycemic control may be beneficial for this patient population.
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