Evidence map›Paper›PMID 39551868›Full record

ArticleOncogene2025

LINC00882, transcriptionally activated by CEBP-β and post-transcriptionally stabilized by METTL14-mediated m

Zhao-Xin Gao, Chun-Lan Li, Han Zhang, Guo-Hao Zhang, Yu Zhang, Xiang-Yu Guo, Zhi-Yuan Tang, Peng Gao, Hai-Ting Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. The mMolecular biomedicine · 2025
    Review
  7. Targeting RNA adenosine editing and modification enzymes for RNA therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhao-Xin Gao *Department of Pathology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Chun-Lan Li *Department of Pathology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Han ZhangDepartment of Pathology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Guo-Hao ZhangDepartment of Pathology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Yu ZhangDepartment of Pathology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Xiang-Yu GuoDepartment of Pathology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Zhi-Yuan TangDepartment of Pathology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Peng GaoDepartment of Pathology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China. gaopeng@sdu.edu.cn.ORCID http://orcid.org/0000-0002-4721-0887
Hai-Ting LiuDepartment of Pathology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China. liuhaiting@sdu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82103564National Natural Science Foundation of China (National Science Foundation of China) 82273378
6 · The paper itself

Abstract

Breast cancer (BC) is the most common malignant tumor in women, and the majority of BC-related deaths are due to tumor metastasis. There is emerging evidence for the role of long noncoding RNAs (lncRNAs) in tumor progression. Nevertheless, lncRNAs that drive metastasis in patients with BC and the underlying mechanisms of lncRNAs are still largely elusive. In this study, we showed that LINC00882 was highly expressed in metastatic BC tissues, and a receiver operating characteristic (ROC) curve was able to distinguish well between BC cases with lymph node metastasis (LNM) and those without LNM. Functionally, LINC00882 promoted BC invasion and metastasis in vitro and in vivo. Mechanistically, at the transcriptional level, CEBP-β could bind directly to the LINC00882 promoter region and activate its transcription. Moreover, at the posttranscriptional level, m

Indexed as

Breast NeoplasmsCCAAT-Enhancer-Binding Protein-betaMethyltransferasesRNA, Long NoncodingAdenosineAnimalsCarcinogenesisCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMiceProto-Oncogene Proteins c-etsRNA, MessengerRNA StabilityAdenosineCCAAT-Enhancer-Binding Protein-betaCEBPB protein, humanElk3 protein, humanMethyltransferasesN-methyladenosineProto-Oncogene Proteins c-etsRNA, Long NoncodingRNA, Messenger

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.