Evidence map›Paper›PMID 39553867›Full record

ArticleBiomedical optics express2024

Video-rate two-photon microendoscopy using second harmonic resonance fiber scanning.

Kai Zhang, Guillaume Ducourthial, Taresh Sharan, Arvind Mohan, Jiasen Hou, Sudip Timilsina, Rongguang Liang, Frederic Louradour, Bryan Q Spring

Abstract read
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kai ZhangDepartment of Physics, Northeastern University, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0002-5954-5764
Guillaume DucourthialDepartment of Physics, Northeastern University, Boston, MA 02115, USA.
Taresh SharanDepartment of Physics, Northeastern University, Boston, MA 02115, USA.
Arvind MohanTranslational Biophotonics Cluster, Northeastern University, Boston, MA 02115, USA.
Jiasen HouDepartment of Physics, Northeastern University, Boston, MA 02115, USA.
Sudip TimilsinaDepartment of Physics, Northeastern University, Boston, MA 02115, USA.
Rongguang LiangWyant College of Optical Sciences, The University of Arizona, Tucson, AZ 85721, USA.ORCID https://orcid.org/0000-0003-2792-3457
Frederic LouradourXLIM, Université de Limoges, France.
Bryan Q SpringDepartment of Physics, Northeastern University, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0001-7332-7707

Funding

Small Molecule Enhancers of Photodynamic Therapy for Skin CancerP01CA084203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Brian William Pogue · 2001 to 2026
$27.9M
Multiplexed and dynamically targeted photoimmunotherapy of heterogeneous, chemoresistant micrometastases guided by online in vivo optical imaging of cell-surface biomarkersR01CA226855 · NCI · NORTHEASTERN UNIVERSITY · PI SPRING, BRYAN QUILTY · 2020 to 2024
$3.1M
NCI NIH HHS P01 CA084203NCI NIH HHS R01 CA226855
6 · The paper itself

Abstract

We present a 2.5-mm-diameter resonant fiber scanning two-photon microendoscope with a 30-mm long forward-viewing rigid probe tip that enables video-rate imaging (20 Hz frame rate) suitable for hand-held imaging of tissues without motion artifacts. Higher-order harmonic oscillation scanning techniques are developed to significantly increase the frame rate compared to prior published fiber scanning microendoscopy designs while maintaining the field-of-view (∼125 µm), the optical resolution (1.2 µm lateral and 10.9 µm axial resolution, full width at half maximum), and the spatial sampling (1250 circumferential pixels per spiral × 20 radial pixels over the diameter; 210 spirals per frame, ∼4 spiral samples per resolvable pixel) compared to a traditional scan using the fundamental resonance. 3D printed mounts were created to reduce the cost and simplify the fabrication for the fiber scanner without compromising performance or stability (<0.3 µm drift over 84 hours). A custom long-wavelength (∼1.08 µm) femtosecond fiber laser is coupled into several meters of fiber to realize a flexible, hand-held device for long-wavelength multiphoton microendoscopy.

Identifiers

PMID39553867
PMCPMC11563328

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.