Evidence map›Paper›PMID 39553877›Full record

ArticleBiomedical optics express2024

Multiphoton scaling of femtosecond laser-induced refractive index change (LIRIC) in hydrogels and rabbit cornea.

Kaitlin T Wozniak, Zachary A Manning, Ruiting Huang, Steven Cox, Sam C Butler, Sebastian Ferlo, Len Zheleznyak, Lisen Xu, Jonathan D Ellis, Krystel R Huxlin and 1 more

Abstract read
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kaitlin T WozniakThe Flaum Eye Institute, University of Rochester, Rochester, NY 14642, USA.
Zachary A ManningThe Institute of Optics, University of Rochester, Rochester, NY 14627, USA.
Ruiting HuangThe Center for Visual Science, University of Rochester, Rochester, NY 14627, USA.
Steven CoxClerio Vision Inc., Rochester, NY 14618, USA.
Sam C ButlerClerio Vision Inc., Rochester, NY 14618, USA.
Sebastian FerloClerio Vision Inc., Rochester, NY 14618, USA.
Len ZheleznyakThe Center for Visual Science, University of Rochester, Rochester, NY 14627, USA.
Lisen XuClerio Vision Inc., Rochester, NY 14618, USA.
Jonathan D EllisThe Institute of Optics, University of Rochester, Rochester, NY 14627, USA.ORCID https://orcid.org/0000-0001-6795-9951
Krystel R HuxlinThe Flaum Eye Institute, University of Rochester, Rochester, NY 14642, USA.ORCID https://orcid.org/0000-0001-7138-6156
Wayne H KnoxThe Center for Visual Science, University of Rochester, Rochester, NY 14627, USA.

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI MICHELE RUCCI · 1985 to 2026
$17.5M
NEI NIH HHS P30 EY001319
6 · The paper itself

Abstract

To find optimal conditions for performing laser induced refractive index change (LIRIC) in living eyes with both safety and efficacy, we investigated multiphoton excitation scaling of this procedure in hydrogel and excised corneal tissue. Three distinct wavelength modalities were examined: high-repetition-rate (HRR) and low-repetition-rate (LRR) 405 nm systems, as well as 800 nm and 1035 nm systems, whose LIRIC-inducing properties are described for the first time. Of all the systems, LRR 405 nm-LIRIC was able to produce the highest phase shifts at the lowest average laser powers. Relative merits and drawbacks to each modality are discussed as they relate to future efforts towards LIRIC-based refractive error correction in humans.

Identifiers

PMID39553877
PMCPMC11563327

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.