Evidence map›Paper›PMID 39553953›Full record

ArticlebioRxiv : the preprint server for biology2024

Dampened α7 nAChR activity contributes to audiogenic seizures and hyperactivity in a mouse model of Fragile X Syndrome.

Sarah Goebel, Dylann Cordova-Martinez, Vytas K Verselis, Anna Francesconi

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah GoebelDepartment of Neuroscience, Albert Einstein College of Medicine; New York, NY, U.S.A.ORCID 0000-0003-1779-3724
Dylann Cordova-MartinezDepartment of Neuroscience, Albert Einstein College of Medicine; New York, NY, U.S.A.ORCID 0000-0003-4209-3834
Vytas K VerselisDepartment of Neuroscience, Albert Einstein College of Medicine; New York, NY, U.S.A.ORCID 0000-0001-6647-1102
Anna FrancesconiDepartment of Neuroscience, Albert Einstein College of Medicine; New York, NY, U.S.A.ORCID 0000-0003-1765-3246

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Support for the Rose F. Kennedy IDDRCU54HD090260 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MORROW, BERNICE E · 2016 to 2020
$6.0M
Metabotropic glutamate receptor functions in autophagyR01MH108614 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FRANCESCONI, ANNA · 2016 to 2020
$2.3M
Zeiss Confocal Microscope with Airyscan for Einstein Neural Cell Engineering and Imaging CoreS10OD025295 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DOBRENIS, KOSTANTIN · 2019 to 2019
$523k
NICHD NIH HHS P50 HD105352NICHD NIH HHS U54 HD090260NIH HHS S10 OD025295NIMH NIH HHS R01 MH108614
6 · The paper itself

Abstract

Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability and often accompanied with debilitating pathologies including seizures and hyperactivity. FXS arises from a trinucleotide repeat expansion in the 5' UTR of the

Identifiers

PMID39553953
PMCPMC11566027

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.