Evidence map›Paper›PMID 39554135›Full record

ArticlebioRxiv : the preprint server for biology2025

Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans.

Zachary P Rosenthal, Joseph B Majeski, Ala Somarowthu, Davin K Quinn, Britta E Lindquist, Mary E Putt, Antoneta Karaj, Chris G Favilla, Wesley B Baker, Golkoo Hosseini and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Zachary P RosenthalPsychiatry Residency Physician-Scientist Research Track, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-8787-0858
Joseph B MajeskiDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA.
Ala SomarowthuDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, PA, USA.
Davin K QuinnDepartment of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Britta E LindquistDepartment of Neurology, University of California San Francisco School of Medicine, San Francisco, CA, USA.
Mary E PuttDepartment of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Antoneta KarajDepartment of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chris G FavillaDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wesley B BakerDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, PA, USA.
Golkoo HosseiniDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jenny P RodriguezDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mario A CristanchoDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yvette I ShelineDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6929-9659
C William ShuttleworthDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Christopher C AbbottDepartment of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Arjun G YodhDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA.
Ethan M GoldbergDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, PA, USA.

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ERIC D MARSH, ROBERT Thomas SCHULTZ · 2021 to 2026
$9.2M
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)R25NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSEPHSON, SCOTT ANDREW · 2010 to 2023
$6.8M
Spreading Depolarizations and Post-Ischemic InjuryR01NS051288 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2006 to 2014
$2.6M
NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)UE5NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Scott Andrew Josephson · 2024 to 2026
$2.6M
Spreading Depolarizations and Neuronal VulnerabilityR01NS106901 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Claude W Shuttleworth · 2018 to 2026
$2.5M
Educating Physician Scientists in Psychiatry (EPSP): Firing up the next generation of translational and clinical neuroscientistsR25MH119043 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Mariella De Biasi, MATTHEW S KAYSER · 2019 to 2026
$1.6M
Adenosine receptor activation in spreading depolarization and ischemic injuryF31NS078805 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LINDQUIST, BRITTA · 2012 to 2014
$93k
NCATS NIH HHS UL1 TR001878NIBIB NIH HHS P41 EB029460NICHD NIH HHS P50 HD105354NIMH NIH HHS R25 MH119043NINDS NIH HHS F31 NS078805NINDS NIH HHS R01 NS051288NINDS NIH HHS R01 NS106901NINDS NIH HHS R25 NS070680NINDS NIH HHS UE5 NS070680
6 · The paper itself

Abstract

Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to generating a controlled seizure; however, the underlying neurobiology is understudied and unresolved. Using optical neuroimaging of neural activity and hemodynamics in a mouse model of ECT, we demonstrated that a second brain event follows seizure: cortical spreading depolarization (CSD). We found that ECT pulse parameters and electrode configuration directly shaped the wave dynamics of seizure and subsequent CSD. To translate these findings to human patients, we used non-invasive diffuse optical monitoring of cerebral blood flow and oxygenation during routine ECT treatments. We observed that human brains reliably generate hyperemic waves after ECT seizure which are highly consistent with CSD. These results challenge a long-held assumption that seizure is the primary outcome of ECT and point to new opportunities for optimizing ECT stimulation parameters and treatment outcomes.

Identifiers

PMID39554135
PMCPMC11565954

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.