Evidence map›Paper›PMID 39554136›Full record

ArticlebioRxiv : the preprint server for biology2024

Exploring Arylidene-Indolinone Ligands of Autophagy Proteins LC3B and GABARAP.

Alexandria N Leveille, Thomas Schwarzrock, Hawley Brown, Bennett True, Joanet Plasencia, Philipp Neudecker, Alina Üffing, Oliver H Weiergräber, Dieter Willbold, Joshua A Kritzer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alexandria N LeveilleDepartment of Chemistry, Tufts University, 62 Talbot Avenue, Medford MA, USA.ORCID 0000-0002-0534-4828
Thomas SchwarzrockDepartment of Chemistry, Tufts University, 62 Talbot Avenue, Medford MA, USA.
Hawley BrownDepartment of Chemistry, Tufts University, 62 Talbot Avenue, Medford MA, USA.
Bennett TrueDepartment of Chemistry, Tufts University, 62 Talbot Avenue, Medford MA, USA.
Joanet PlasenciaDepartment of Chemistry, Tufts University, 62 Talbot Avenue, Medford MA, USA.
Philipp NeudeckerHeinrich-Heine-Universität Düsseldorf, Mathematisch-Naturwissenschaftliche Fakultät, Institut für Physikalische Biologie, 40225 Düsseldorf, Germany.ORCID 0000-0002-0557-966X
Alina ÜffingHeinrich-Heine-Universität Düsseldorf, Mathematisch-Naturwissenschaftliche Fakultät, Institut für Physikalische Biologie, 40225 Düsseldorf, Germany.
Oliver H WeiergräberHeinrich-Heine-Universität Düsseldorf, Mathematisch-Naturwissenschaftliche Fakultät, Institut für Physikalische Biologie, 40225 Düsseldorf, Germany.
Dieter WillboldHeinrich-Heine-Universität Düsseldorf, Mathematisch-Naturwissenschaftliche Fakultät, Institut für Physikalische Biologie, 40225 Düsseldorf, Germany.
Joshua A KritzerDepartment of Chemistry, Tufts University, 62 Talbot Avenue, Medford MA, USA.ORCID 0000-0003-2878-6781

Funding

Diversity Supplement for Imani McDonald - Developing Autophagy-Targeting Chimeras and Optimizing Cell Penetration of Large-Molecule TherapeuticsR35GM148407 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI Joshua A Kritzer · 2023 to 2026
$2.6M
NIGMS NIH HHS R35 GM148407
6 · The paper itself

Abstract

We report the first structure-activity studies of arylidene-indolinone compound

Indexed as

autophagyprotein-protein interactionssmall-molecule inhibitorsstructure-activity relationships

Identifiers

PMID39554136
PMCPMC11565829

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.