Evidence map›Paper›PMID 39556486›Full record

ArticleJournal of diabetes investigation2025

Is glucose-induced hypersecretion of glicentin after the revision surgery using Roux-en-Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy?

Yukako Yamamoto, Osamu Sekine, Jun Ito-Kobayashi, Ayane Nishida, Takeshi Togawa, Yuki Ozamoto, Yasumitsu Oe, Akeo Hagiwara, Masaki Kobayashi, Tadahiro Kitamura and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yukako YamamotoDepartment of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan.
Osamu SekineDepartment of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan.
Jun Ito-KobayashiDepartment of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan.
Ayane NishidaDepartment of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan.
Takeshi TogawaDepartment of Bariatric and Metabolic Surgery, Omi Medical Center, Kusatsu, Shiga, Japan.
Yuki OzamotoDepartment of Bariatric and Metabolic Surgery, Omi Medical Center, Kusatsu, Shiga, Japan.
Yasumitsu OeDepartment of Bariatric and Metabolic Surgery, Omi Medical Center, Kusatsu, Shiga, Japan.
Akeo HagiwaraDepartment of Bariatric and Metabolic Surgery, Omi Medical Center, Kusatsu, Shiga, Japan.
Masaki KobayashiMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Tadahiro KitamuraMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.ORCID https://orcid.org/0000-0001-8809-8740
Masanori IwanishiDepartment of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan.ORCID https://orcid.org/0000-0002-5390-1000
Akira ShimatsuDepartment of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan.
Atsunori KashiwagiDepartment of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan.ORCID https://orcid.org/0000-0002-6049-3236

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report case details of a morbidly obese patient with type 2 diabetes mellitus (T2DM) who became a failure of diabetes remission after laparoscopic sleeve gastrectomy (LSG). He had a marked improvement of hyperglycemia after the revision surgery using Roux-en-Y gastric bypass (RYGB), where passage failure of a solid food intake at the gastric angle portion disappeared after the revision surgery. Interestingly, he showed improvements of insulin and a marked glicentin secretions with minor changes in glucagon related peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) secretions in the oral glucose tolerance test OGTT after the RYGB surgery compared with post-LSG. Although a marked increase in glucose-induced glicentin secretion after RYGB surgery with increased insulin secretion, further studies are needed to confirm if the increased glicentin secretion after RYGB surgery is linked to stimulation of insulin secretion.

Indexed as

Diabetes Mellitus, Type 2GastrectomyGastric BypassGlicentinInsulinBlood GlucoseGlucoseGlycemic ControlHumansInsulin SecretionLaparoscopyMaleMiddle AgedObesity, MorbidReoperationBlood GlucoseGlicentinGlucoseInsulinglicentinglycemic controlinsulin secretionmetabolic surgery

Identifiers

PMID39556486
PMCPMC11786166

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.