Evidence map›Paper›PMID 39556808›Full record

ArticleDiabetes2025

Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes.

Delnaz Roshandel, Athina Spiliopoulou, Stuart J McGurnaghan, Andrii Iakovliev, Debby Lipschutz, Caroline Hayward, Shelley B Bull, Barbara E K Klein, Kristine E Lee, Gregory L Kinney and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Delnaz RoshandelGenetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0002-4902-8587
Athina SpiliopoulouUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K.
Stuart J McGurnaghanInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, U.K.ORCID 0000-0002-3292-4633
Andrii IakovlievUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K.
Debby LipschutzUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K.
Caroline HaywardInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, U.K.
Shelley B BullLunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada.
Barbara E K KleinSchool of Medicine and Public Health, Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI.ORCID 0000-0003-2379-976X
Kristine E LeeSchool of Medicine and Public Health, Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI.
Gregory L KinneyDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO.
Marian RewersBarbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
Tina CostacouDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0001-9303-3810
Rachel G MillerDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0003-1845-8477
Paul M McKeigueUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K.ORCID 0000-0002-5217-1034
Andrew D PatersonGenetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.
Helen M ColhounInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, U.K.ORCID 0000-0002-8345-3288

Funding

ZOPOLRESTAT PHARMACOKINETICS IN DIABETICS WITH VARYING RENAL FUNCTIONM01RR000051 · NCRR · UNIVERSITY OF COLORADO DENVER · PI CAMPBELL, THOMAS A · 1985 to 2008
$52.6M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
EPIDEMIOLOGY OF DIABETIC COMPLICATIONS--PHASE IIR01DK034818 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COSTACOU, TINA · 1986 to 2019
$5.6M
SUBCLINICAL HEART DISEASE IN INSULIN-DEPENDENT DIABETESR01HL061753 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J. · 1999 to 2007
$5.2M
Complications and Comorbidities of Type 1 DiabetesR01HL113029 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SNELL-BERGEON, JANET KATHLEEN · 2013 to 2016
$2.9M
Determinants of Accelerated CVD in Type 1 DiabetesR01HL079611 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J. · 2004 to 2007
$2.3M
Academy of Medical Sciences SBF006/1109British Heart FoundationCanadian Institute of Health Research UCD-170583Chief Scientist Office of the Scottish Government ETM/47Chief Scientist Office of the Scottish Government Health Directorates CZD/16/6Diabetes UK 10/0004010Juvenile Diabetes Research Fund 17-2013-7Medical Research Council MR/T032340/1MRC Human Genetics Unit U. MC_UU_00007/10NCATS NIH HHS UL1 TR002535NCRR NIH HHS M01 RR000051NHLBI NIH HHS R01 HL061753NHLBI NIH HHS R01 HL079611NHLBI NIH HHS R01 HL113029NIDDK NIH HHS P30 DK057516NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK034818NIH HHS M01 RR000051/RR/NCRRScottish Diabetes Research NetworkScottish Funding Council HR03006UK Government Department of Business, Energy and Indus- trial StrategyWellcome Trust
6 · The paper itself

Abstract

article highlightsIdentified genetic loci for C-peptide and type 1 diabetes (T1D) age at diagnosis (AAD) explain only a small proportion of their variation. We aimed to identify additional genetic loci associated with C-peptide and AAD. Some HLA allele/haplotypes associated with T1D also contributed to variability of C-peptide and AAD, whereas outside the HLA region, T1D loci were mostly not associated with C-peptide or AAD. Genetic variation within CTSH can affect AAD. There is still residual heritability of C-peptide and AAD outside of HLA that could benefit from larger meta-genome-wide association studies.

Indexed as

C-PeptideDiabetes Mellitus, Type 1Age of OnsetChildFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesHLA AntigensHumansMalePolymorphism, Single NucleotideC-PeptideHLA Antigens

Identifiers

PMID39556808
PMCPMC11755686

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.