ArticleNature communications2024
Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reservoir differences across HIV-1 subtypes: a systematic review to guide cure research.Frontiers in immunology · 2026Pooled it
- Association between baseline HIV-1 DNA levels and clinical outcomes in people living with HIV: a meta-analysis of cohort studies.Emerging microbes & infections · 2025Pooled it
- Intact and Defective HIV Provirus Changes During Antiretroviral Therapy in People Treated During Acute or Chronic HIV Infection or as HIV Controllers.Open forum infectious diseases · 2025Trial
- Early intervention, lasting impact: benefits of early antiretroviral therapy and implications for posttreatment control.Current opinion in HIV and AIDS · 2026Review
- Article
- Recommendations from the 2nd Consensus Workshop on Analytical Treatment Interruption in HIV Research Trials.The lancet. HIV · 2026Article
- Article
- Astragalus polysaccharide promotes latent HIV-1 reactivation via exosome-mediated modulation of the PI3K/AKT/NF-κB axis.Extracellular vesicles and circulating nucleic acids · 2026Article
- Modeling of H5N1 influenza virus kinetics during dairy cattle infection suggests the timing of infectiousness.PLoS biology · 2026Article
- The effect of combining HIV latency reversal with inhibition of phosphoinositide-3 kinases or B-cell lymphoma-2 on the HIV reservoir.PLoS pathogens · 2026Article
- The performance of low HIV viral load values for the diagnosis of acute HIV infection in the Beijing PRIMO cohort.BMC infectious diseases · 2025Article
- Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden.Journal of theoretical biology · 2025Article
- Selective decline of intact HIV reservoirs during the first decade of ART followed by stabilization in memory T cell subsets.AIDS (London, England) · 2025Article
- Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts.Nature communications · 2025Article
- Intact HIV DNA decays in children with and without complete viral load suppression.PLoS pathogens · 2025Article
- Longitudinal changes in the transcriptionally active and intact HIV reservoir after starting ART during acute infection.Journal of virology · 2025Article
- Defective proviruses significantly impact viral transcription and immune activation in men and women with HIV-1 subtype C in rural South Africa.Frontiers in immunology · 2024Article
Corrections and comments
- Update of
Authors and funding
26 authors.
Alton Barbehenn *Department of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA. altonbarbehenn@gmail.com.ORCID 0009-0000-3364-7204
Lei Shi *Department of Biostatistics, University of California Berkeley, Berkeley, CA, USA.
Junzhe ShaoDepartment of Biostatistics, University of California Berkeley, Berkeley, CA, USA.
Rebecca HohDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.
Heather M HartigDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.
Vivian PaeDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0008-2415-6647
Sannidhi SarvadhavabhatlaDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0003-8326-8423
Sophia DonaireDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0007-9647-2473
Caroline SheikhzadehDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0000-2631-9827
Jeffrey MilushDepartment of Medicine, Division of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.
Gregory M LairdAccelevirDiagnostics, Baltimore, MD, USA.
Mignot MathiasAccelevirDiagnostics, Baltimore, MD, USA.
Kristen RitterAccelevirDiagnostics, Baltimore, MD, USA.
Michael J PelusoDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0585-6230
Jeffrey MartinDepartment of Biostatistics & Epidemiology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9773-3256
Frederick HechtDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5782-1171
Christopher PilcherDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.
Stephanie E CohenDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1632-1074
Susan BuchbinderSan Francisco Department of Public Health, San Francisco, CA, USA.ORCID 0000-0003-2404-0712
Diane HavlirDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.
Monica GandhiDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.
Timothy J HenrichDepartment of Medicine, Division of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6684-0622
Hiroyu HatanoDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3606-0772
Jingshen WangDepartment of Biostatistics, University of California Berkeley, Berkeley, CA, USA.
Steven G DeeksDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6371-747X
Sulggi A LeeDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA, USA. sulggi.lee@ucsf.edu.ORCID 0000-0003-1560-2250
Funding
Delaney AIDS Research Enterprise to Cure HIVUM1AI164560 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS, Sharon Ruth Lewin · 2021 to 2026
$32.0MCentralized Resource to Accurately Quantify Latent and Expressed HIV ReservoirsU24AI143502 · NIAID · ACCELEVIR DIAGNOSTICS, LLC · PI LAIRD, GREGORY MICHAEL, MARTIN, ALBINE · 2020 to 2024
$4.9MTargeting Non Viral Markers of HIV PersistenceR01AI141003 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENRICH, TIMOTHY JENSEN · 2018 to 2022
$4.9MCentralized Resource to Accurately Quantify Latent and Expressed HIVReservoirsR24AI143502 · NIAID · ACCELEVIR DIAGNOSTICS, LLC · PI Gregory Michael Laird, Albine Martin · 2025 to 2026
$2.1MA pharmacogenomics study of HIV latency: the role of PD-1 signalingK23GM112526 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, SULGGI ANGELA · 2014 to 2018
$908kMentoring Scientists for Careers in HIV Translational Clinical ResearchK24AI174971 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Timothy Jensen Henrich · 2023 to 2026
$766kamfAR, The Foundation for AIDS Research (amfAR) 108072-50-RGRLDelaney AIDS Research Enterprise (DARE) UM1AI164560Gilead Sciences (Gilead) IN-US-236-1354NIAID NIH HHS K24 AI174971NIAID NIH HHS R24 AI143502NIAID NIH HHS U24 AI143502NIAID NIH HHS UM1 AI164560NIGMS NIH HHS K23 GM112526U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health) K23GM112526U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01A141003ViiV Healthcare A126326
Abstract
Despite antiretroviral therapy (ART), HIV persists in latently-infected cells (the HIV reservoir) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people living with HIV (PLWH) treated during acute infection, we developed a mathematical model to predict reservoir decay from peripheral CD4 + T cells. Nonlinear generalized additive models demonstrated rapid biphasic decay of intact DNA (week 0-5: t
Indexed as
CD4-Positive T-LymphocytesDNA, ViralHIV-1HIV InfectionsViral LoadVirus LatencyAcute DiseaseAdultAnti-HIV AgentsCD4 Lymphocyte CountFemaleHumansLongitudinal StudiesMaleMiddle AgedModels, TheoreticalAnti-HIV AgentsDNA, Viral
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.