Evidence map›Paper›PMID 39557854›Full record

ArticleNature communications2024

G

Srinivas Pittala, Dhanush Haspula, Yinghong Cui, Won-Mo Yang, Young-Bum Kim, Roger J Davis, Allison Wing, Yaron Rotman, Owen P McGuinness, Asuka Inoue and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Activation of GScience advances · 2026
    Article
  3. Overview of the DREADDs chemogenetics and the patent landscape of their actuators.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. G proteins of the GScience advances · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Srinivas PittalaMolecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, NIH, Bethesda, MD, USA. Srinivas.pittala@nih.gov.ORCID 0000-0002-8873-1320
Dhanush HaspulaMolecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, NIH, Bethesda, MD, USA.
Yinghong CuiMolecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, NIH, Bethesda, MD, USA.
Won-Mo YangDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6742-720X
Young-Bum KimDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9471-6330
Roger J DavisProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-0130-1652
Allison WingLiver & Energy Metabolism Section, Liver Diseases Branch, NIDDK, NIH, Bethesda, MD, USA.ORCID 0009-0001-8993-199X
Yaron RotmanLiver & Energy Metabolism Section, Liver Diseases Branch, NIDDK, NIH, Bethesda, MD, USA.ORCID 0000-0002-7549-8216
Owen P McGuinnessDepartments of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN, USA.ORCID 0000-0002-1778-3203
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.ORCID 0000-0003-0805-4049
Jürgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, NIH, Bethesda, MD, USA. jurgenw@niddk.nih.gov.ORCID 0000-0003-0818-1232

Funding

Role of G protein-coupled receptors in regulating glucose and energy homeostasisZIADK075021 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WESS, JURGEN · 2009 to 2025
$37.0M
Adipose Tissue Metabolic Stress ResponsesR01DK112698 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2017 to 2025
$4.4M
Rho-kinase signaling in energy balanceR01DK129946 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIM, YOUNG-BUM · 2022 to 2025
$2.7M
Programmed Changes in Alternative Splicing Within the Erythroid TranscriptomeR21DK075021 · NIDDK · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CONBOY, JOHN G · 2006 to 2007
$462k
NIDDK NIH HHS R01 DK112698NIDDK NIH HHS R01 DK129946NIDDK NIH HHS R21 DK075021U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK075021
6 · The paper itself

Abstract

Altered hepatic glucose fluxes are critical during the pathogenesis of type 2 diabetes. G protein-coupled receptors represent important regulators of hepatic glucose production. Recent studies have shown that hepatocytes express GPCRs that can couple to G

Indexed as

GlucoseGTP-Binding Protein alpha Subunits, G12-G13HepatocytesHomeostasisLiverSignal TransductionAnimalsFemaleHumansHyperglycemiaInsulin ResistanceMaleMiceMice, Inbred C57BLrho-Associated KinasesSphingosine-1-Phosphate ReceptorsGlucoseGTP-Binding Protein alpha Subunits, G12-G13rho-Associated KinasesSphingosine-1-Phosphate Receptors

Identifiers

PMID39557854
PMCPMC11574106

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.