Evidence map›Paper›PMID 39557857›Full record

ArticleScientific reports2024

Evaluating the impact of Xanthoparmelia conspersa extracts on signaling in HeLa cells and exploring their diverse biological activities.

Grażyna Łaska, Elwira Sieniawska, Łukasz Świątek, Jakub Czapiński, Adolfo Rivero-Müller, Sylwia Kiercul, Babu Lal Tekwani, David S Pasco, Premalatha Balachandran

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Grażyna ŁaskaDepartment of Agri-Food Engineering and Environmental Management, Bialystok University of Technology, Bialystok, 15-351, Poland.
Elwira SieniawskaDepartment of Natural Products Chemistry, Medical University of Lublin, Lublin, 20-093, Poland. esieniawska@pharmacognosy.org.
Łukasz ŚwiątekDepartment of Virology with Viral Diagnostics Laboratory, Medical University of Lublin, Lublin, 20-093, Poland.
Jakub CzapińskiDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, 20-093, Poland.
Adolfo Rivero-MüllerDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, Lublin, 20-093, Poland.
Sylwia KierculDepartment of Agri-Food Engineering and Environmental Management, Bialystok University of Technology, Bialystok, 15-351, Poland.
Babu Lal TekwaniNational Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
David S PascoNational Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
Premalatha BalachandranNational Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA. prembala@olemiss.edu.

Funding

Ministry of Science and Higher Education of Poland WZ/WB-IIS/4/2023University of Mississippi Medical Center Cancer Institute Agreement #10001549University of Mississippi Medical Center Cancer Institute Agreement #64580110000
6 · The paper itself

Abstract

Xanthoparmelia conspersa is rich in specific secondary metabolites but an unexplored lichen species. This work determined the chemical composition and biological activities (anti-microbial, anti-protozoal, and cytotoxic) of its methanolic and hexane extracts. Additionally, we evaluated the potential of these extracts in modulating cancer signaling pathways in HeLa cells. The phytochemical analysis revealed that usnic acid was the predominant constituent in the hexane extract, while stictic acid was in the methanolic one. Among tested cell lines (VERO, FaDu, SCC-25, HeLa), cytotoxic selectivity was detected for X. conspersa hexane extract against the FaDu (SI 7.36) and HeLa (SI 2.19) cells. A noticeably better anti-microbial potential was found for hexane extract, however, the overall anti-microbial activity was relatively weak (28, 21, and 20% inhibition of Candida glabrata, Cryptococcus neoformans, and Escherichia coli, respectively). On the contrary, the anti-parasitic action of hexane extract was significant, with an IC

Indexed as

Signal TransductionAnimalsAnti-Infective AgentsBenzofuransHeLa CellsHumansLichensPlant ExtractsAnti-Infective AgentsBenzofuransPlant Extractsusnic acidBiological activityNatural productsReporter gene assaySignaling pathwaysUsnic acidXanthoparmelia conspersa

Identifiers

PMID39557857
PMCPMC11574082

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.