Evidence map›Paper›PMID 39558592›Full record

ArticleBioinformatics (Oxford, England)2024

APAtizer: a tool for alternative polyadenylation analysis of RNA-Seq data.

Bruno Sousa, Maria Bessa, Filipa L de Mendonça, Pedro G Ferreira, Alexandra Moreira, Isabel Pereira-Castro

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bruno SousaGene Regulation Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal.
Maria BessaGene Regulation Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal.
Filipa L de MendonçaGene Regulation Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal.
Pedro G FerreiraFCUP-Faculdade de Ciências, Universidade do Porto, Porto, 4169-007, Portugal.
Alexandra MoreiraGene Regulation Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal.
Isabel Pereira-CastroGene Regulation Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal.ORCID 0000-0003-4149-4310

Funding

FCT-Fundação para a Ciência e a Tecnologia I.P
6 · The paper itself

Abstract

summaryAPAtizer is a tool designed to analyze alternative polyadenylation events on RNA-sequencing data. The tool handles different file formats, including BAM, htseq, and DaPars bedGraph files. It provides a user-friendly interface that allows users to generate informative visualizations, including Volcano plots, heatmaps, and gene lists. These outputs allow the user to retrieve useful biological insights such as the occurrence of polyadenylation events when comparing two biological conditions. In addition, it can perform differential gene expression, gene ontology analysis, visualization of Venn diagram intersections, and correlation analysis. AVAILABILITY AND IMPLEMENTATION: Source code and example case studies for APAtizer are available at https://github.com/GeneRegulationi3S/APAtizer/.

Indexed as

PolyadenylationSoftwareComputational BiologyHumansRNA-SeqSequence Analysis, RNA

Identifiers

PMID39558592
PMCPMC11601165

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.