Evidence map›Paper›PMID 39558626›Full record

ArticleObesity (Silver Spring, Md.)2024

Weight maintenance on cost-effective antiobesity medications after 1 year of GLP-1 receptor agonist therapy: a real-world study.

Nina U Paddu, Brianna Lawrence, Sydnee Wong, Sabrina J Poon, Gitanjali Srivastava

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. The evolving landscape of obesity pharmacotherapy.Nature reviews. Drug discovery · 2026
    Review
  4. Article
  5. Observational
  6. Review
  7. Article
  8. Review
  9. Article
  10. Evolving Role of GLP-1 Therapies in Liver Disease.Current gastroenterology reports · 2025
    Review
  11. Article
  12. Pharmacotherapy for Obesity: Recent Updates.Clinical pharmacology : advances and applications · 2025
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nina U PadduDepartment of Medicine, Division of Diabetes, Endocrinology & Metabolism, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Brianna LawrenceVanderbilt Weight Loss Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sydnee WongDepartment of Medicine, Division of Diabetes, Endocrinology & Metabolism, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Sabrina J PoonDepartment of Population Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Gitanjali SrivastavaDepartment of Medicine, Division of Diabetes, Endocrinology & Metabolism, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-8326-3089

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe high cost of novel glucagon-like peptide-1 receptor agonist (GLP-1 RA) class agents often limits access and creates barriers to care. This real-world study evaluated the efficacy of older-generation generic antiobesity medications (AOMs) for weight maintenance after 1 year of GLP-1 RA therapy in patients who had achieved successful weight loss.

methodsWe prospectively followed patients (N = 105) who had completed 12 months of therapy and were part of a "medical weight loss bundle," which included 12 months of GLP-1 RA therapy followed by 6 months of transition care. The baseline mean BMI was 36.4 kg/m

resultsAfter the medical weight loss bundle, 40 patients transitioned to generic AOMs. At 12 months, this cohort lost an average of 18.3%, 95% CI [13.0%, 23.6%] body weight from baseline, with a mean BMI of 27.9 kg/m

conclusionsPatients successfully treated with GLP-1 RAs can maintain their weight loss using generic older-generation AOMs, suggesting potential cost savings for insurers and implications for policy regarding AOM coverage.

Indexed as

Anti-Obesity AgentsCost-Benefit AnalysisGlucagon-Like Peptide-1 Receptor AgonistsObesityWeight LossAdultAgedBody Mass IndexBody Weight MaintenanceDrugs, GenericFemaleHumansLiraglutideMaleMiddle AgedProspective StudiesAnti-Obesity AgentsDrugs, GenericGlucagon-Like Peptide-1 Receptor AgonistsLiraglutide

Identifiers

PMID39558626
PMCPMC11589535

What Socratic holds

Texttitle and abstract
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.