Evidence map›Paper›PMID 39561376›Full record

ArticleBlood advances2025

Consensus recommendations from the 2024 Lymphoma Research Foundation workshop on treatment selection and sequencing in CLL or SLL.

Jacob D Soumerai, Jacqueline Barrientos, Inhye Ahn, Catherine Coombs, Douglas Gladstone, Marc Hoffman, Adam Kittai, Ryan Jacobs, Andrew Lipsky, Krish Patel and 8 more

Abstract readConsensus Statement
In one paragraph

Article in Blood advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Management of Relapsed and/or Refractory Chronic Lymphocytic Leukemia.Hematology/oncology clinics of North America · 2025
    Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Jacob D SoumeraiMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-3062-6819
Jacqueline BarrientosMount Sinai Comprehensive Cancer Center, Miami, FL.ORCID 0000-0001-6018-5535
Inhye AhnDana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Catherine CoombsUniversity of California, Irvine, CA.
Douglas GladstoneNorthwell Health Cancer Institute, New Hyde Park, NY.
Marc HoffmanUniversity of Kansas Cancer Center, Overland Park, KS.
Adam KittaiMount Sinai Tisch Cancer Center, New York, NY.
Ryan JacobsWake Forest Levine Cancer Institute, Charlotte, NC.
Andrew LipskyColumbia University Herbert Irving Comprehensive Cancer Center, New York, NY.
Krish PatelSwedish Cancer Institute, Seattle, WA.
Joanna RhodesRutgers Cancer Institute of New Jersey, New Brunswick, NJ.
Alan SkarbnikNovant Health Cancer Institute, Charlotte, NC.
Meghan ThompsonMemorial Sloan Kettering Cancer Institute, New York, NY.ORCID 0000-0003-1462-4802
Daniel ErmannUniversity of Utah Huntsman Cancer Institute, Salt Lake City, UT.
Patrick RevilleMD Anderson Cancer Center, Houston, TX.ORCID 0000-0001-8433-3360
Harsh ShahUniversity of Utah Huntsman Cancer Institute, Salt Lake City, UT.
Jennifer R BrownDana-Farber Cancer Institute, Harvard Medical School, Boston, MA.ORCID 0000-0003-2040-4961
Deborah M StephensLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC.ORCID 0000-0001-9188-5008

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Predictive markers for personalized therapy in chronic lymphocytic leukemiaK08CA270202 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Jacob Soumerai · 2023 to 2026
$1.1M
NCI NIH HHS K08 CA270202NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

abstractOver the past decade, treatment recommendations for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) have shifted from traditional chemoimmunotherapy to targeted therapies. Multiple new therapies are commercially available, and, in many cases, a lack of randomized clinical trial data makes selection of the optimal treatment for each patient challenging. Additionally, many patients continue to receive chemoimmunotherapy in the United States, suggesting a gap between guidelines and real-world practice. The Lymphoma Research Foundation convened a workshop comprising a panel of CLL/SLL experts in the United States to develop consensus recommendations for selection and sequencing of therapies for patients with CLL/SLL in the United States. Herein, the recommendations are compiled for use as a practical clinical guide for treating providers caring for patients with CLL/SLL, which complement existing guidelines by providing a nuanced discussion relating how our panel of CLL/SLL experts in the United States care for patients in a real-world environment.

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellDisease ManagementHumans

Identifiers

PMID39561376
PMCPMC11993837

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.