Evidence map›Paper›PMID 39562136›Full record

ArticleCarbohydrate polymers2025

Comparative analysis of polysaccharide and cell wall structure in Aspergillus nidulans and Aspergillus fumigatus by solid-state NMR.

Isha Gautam, Jayasubba Reddy Yarava, Yifan Xu, Reina Li, Faith J Scott, Frederic Mentink-Vigier, Michelle Momany, Jean-Paul Latgé, Tuo Wang

Abstract readComparative Study
In one paragraph

Article in Carbohydrate polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Profound cell wall remodeling inMicrobiology spectrum · 2026
    Article
  5. Chaotropic Ions Reshape the Cell Wall of the Obligate HalophilebioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Oxidative Stress-Responsive Cell Wall Remodeling Depends on Phosphate inbioRxiv : the preprint server for biology · 2025
    Article
  8. Review
  9. Solid-state NMR spectroscopy reveals unique properties ofCell surface (Amsterdam, Netherlands) · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Isha GautamDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.
Jayasubba Reddy YaravaDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.
Yifan XuDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.
Reina LiDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.
Faith J ScottNational High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA.
Frederic Mentink-VigierNational High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA.
Michelle MomanyFungal Biology Group & Department of Plant Biology, University of Georgia, Athens, GA, USA.
Jean-Paul LatgéInstitute of Molecular Biology and Biotechnology, University of Crete, Heraklion, Greece; Fungal Respiratory Infections Research Unit and SFR ICAT, University of Angers, France.
Tuo WangDepartment of Chemistry, Michigan State University, East Lansing, MI, USA. Electronic address: wangtuo1@msu.edu.

Funding

National Resource for Advanced NMR TechnologyRM1GM148766 · NIGMS · FLORIDA STATE UNIVERSITY · PI William W Brey, Joanna R Long · 2023 to 2026
$4.9M
Revealing the Cell Wall Organization of Fungal Pathogens and Structural Responses to Antifungal Drugs Using Cellular Solid-State NMRR01AI173270 · NIAID · MICHIGAN STATE UNIVERSITY · PI Tuo Wang · 2023 to 2026
$1.5M
NIAID NIH HHS R01 AI173270NIGMS NIH HHS RM1 GM148766
6 · The paper itself

Abstract

Invasive aspergillosis poses a significant threat to immunocompromised patients, leading to high mortality rates associated with these infections. Targeting the biosynthesis of cell wall carbohydrates is a promising strategy for antifungal drug development and will be advanced by a molecular-level understanding of the native structures of polysaccharides within their cellular context. Solid-state NMR spectroscopy has recently provided detailed insights into the cell wall organization of Aspergillus fumigatus, but genetic and biochemical evidence highlights species-specific differences among Aspergillus species. In this study, we employed a combination of

Indexed as

Aspergillus fumigatusAspergillus nidulansCell WallMagnetic Resonance SpectroscopyChitinGalactoseGlucansMannansPolysaccharidesChitingalactomannangalactosaminogalactanGalactoseGlucansMannansPolysaccharidesAspergillusCell wallChitinDNPFungiGlucanPolysaccharideSolid-state NMR

Identifiers

PMID39562136
PMCPMC11576540

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.