Evidence map›Paper›PMID 39562150›Full record

ReviewPhysiological reports2024

Air pollutants as modulators of mitochondrial quality control in cardiovascular disease.

Kit Neikirk, Chanel Harris, Han Le, Ashton Oliver, Bryanna Shao, Kaihua Liu, Heather K Beasley, Sydney Jamison, Jeanne A Ishimwe, Annet Kirabo and 1 more

Abstract readReview
In one paragraph

Review in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kit NeikirkDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Chanel HarrisDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Han LeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Ashton OliverDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Bryanna ShaoDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Kaihua LiuDepartment of Anatomy of Cell Biology, University of Iowa, Iowa City, Iowa, USA.
Heather K BeasleyDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Sydney JamisonDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jeanne A IshimweDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Annet KiraboDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-8580-9359
Antentor HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-7730-952X

Funding

ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6M
The Meharry Research Training InitiativeT32GM144927 · NIGMS · MEHARRY MEDICAL COLLEGE · PI Pamela M Martin · 2022 to 2026
$1.9M
Role of Salt, Isoketal-modified Proteins and Dendritic Cells in HypertensionK01HL130497 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2016 to 2020
$803k
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seqR03HL155041 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2021 to 2022
$173k
American Heart Association (AHA) POST9034281Burroughs Wellcome Fund (BWF) 1021868.01Chan Zuckerberg Initiative (CZI) 2022- 253529HHS | National Institutes of Health (NIH) 5R01HL144941HHS | National Institutes of Health (NIH) 5R25HL106365-12HHS | National Institutes of Health (NIH) K01HL130497HHS | National Institutes of Health (NIH) R01HL147818HHS | National Institutes of Health (NIH) R03HL155041NIGMS NIH HHS T32 GM144927UNCF/BMS EE Just Award Faculty Fund SNF_300440Vanderbilt Diabetes and Research Training Center Alzheimer's Disease Pilot & Feasibility Program DK020593
6 · The paper itself

Abstract

It is important to understand the effects of environmental factors such as air pollution on mitochondrial structure and function, especially when these changes increase cardiovascular disease risk. Although lifestyle choices directly determine many mitochondrial diseases, increasingly, it is becoming clear that the structure and function of mitochondria may be affected by pollutants found in the atmosphere (e.g., gases, pesticides herbicide aerosols, or microparticles). To date, the role of such agents on mitochondria and the potential impact on cardiovascular fitness is neglected. Here we offer a review of airborne stressors and pollutants, that may contribute to impairments in mitochondrial function and structure to cause heart disease.

Indexed as

Air PollutantsCardiovascular DiseasesAnimalsHumansMitochondriaAir Pollutantscardiovascular diseaseenvironmentmitochondriapollutantstoxicology

Identifiers

PMID39562150
PMCPMC11576129

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.