ArticleDiabetes, obesity & metabolism2025
Circulating inflammatory proteins are elevated in type 1 and type 2 diabetes and associated to complications.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Type 1 diabetes alters early macrophage-iScience · 2026Article
- hs-CRP/HDL Ratio Across Obesity and Type 2 Diabetes Mellitus Phenotypes in Adults: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
- Joint association of TyG-ABSI composite index and inflammatory score with diabetes in middle-aged and older Chinese adults: a prospective cohort study from CHARLS (2011-2020).BMC endocrine disorders · 2026Article
- Systemic Inflammation and Peripheral T Cell Responses Associate With Hepatic Energy Metabolism in Recent-Onset Type 1 Diabetes.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Mechanisms and Production of Hypoglycaemic Peptides: Exploring the Potential ofFood science & nutrition · 2026Review
- Biomaterial regulation of excessive inflammation restores osteoimmune homeostasis in diabetic bone regeneration.Regenerative biomaterials · 2026Review
- Early detection of positive urine culture in patients with urolithiasis: a machine learning model with dynamic online nomogram.Annals of medicine · 2025Article
- Potential Molecular Biomarkers for Predicting and Monitoring Complications in Type 2 Diabetes Mellitus.Molecules (Basel, Switzerland) · 2025Review
- Prognostic Value of the Charlson Comorbidity Index for Mortality and Machine Learning-Based Prediction in Critically Ill Patients with Paralytic Ileus: Retrospective Cohort Study.JMIR medical informatics · 2025Article
- Inflammation and dyslipidaemia in combined diabetes and tuberculosis; a cohort study.iScience · 2025Article
- [Oxidative Stress Induced by High Glucose Aggravates Immunosuppression in Diabetes Mellitus by Promoting Effector T Cell Apoptosis and Regulatory T Cell Differentiation].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Circulating inflammatory proteins are elevated in type 1 and type 2 diabetes and associated to complications.Diabetes, obesity & metabolism · 2025Article
- Multi-omics-driven biomarker discovery in autoimmune diseases: a comprehensive review.Frontiers in immunology · 2025Review
- Remnant Cholesterol Inflammatory Index and New-Onset Diabetes in Middle-Aged and Older Adults: Evidence From Prospective Surveys of Chinese and UK Populations.Journal of diabetes research · 2025Article
- Linking high-sensitivity C-reactive protein and dyslipidemia among patients with type 2 diabetes mellitus.Bioinformation · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe presence of low-grade inflammation has been reported in people with type 2 diabetes and related to the development of (macro)vascular complications. Whether systemic inflammation is present in type 1 diabetes and linked to long-term complications remains unknown. We used a targeted proteomics approach to compare inflammation in people with type 1 diabetes and type 2 diabetes with control subjects and linked these proteins to diabetes related characteristics and complications.
methodsWe included 233 participants with type 1 diabetes, 387 participants with type 2 diabetes and 150 healthy controls. Plasma was collected and used to determine high sensitive C-reactive proteins (hs-CRP) and an additional 92 inflammatory proteins using the Olink proteomics platform.
resultsCompared to healthy controls, 41 circulating inflammatory proteins were higher in type 1 diabetes (FDR < 0.05) and 64 inflammatory proteins in type 2 diabetes (FDR < 0.05) (including CXCL5, IL-15RA, MCP-4 and AXIN1 for both groups). HbA
conclusionsBoth type 1 diabetes and type 2 diabetes are associated with increased circulating inflammatory protein concentrations, but the increase is more pronounced in type 2 diabetes. These results suggest both differences in drivers of inflammation between type 1 diabetes and type 2 diabetes as well as potential similarities in pathways involved in the development of diabetes-associated complications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.