Effects and mechanisms of dexmedetomidine preconditioning on isoproterenol-induced ventricular arrhythmias.

Shengji Duan, Xueru Liu, Jianhong Li, Yangpeng Li, Tangting Chen, Shuzhi Zhou

Abstract read

In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shengji Duan *Department of Anesthesiology, The Second People's Hospital of Yibin, Yibin, 644000, Sichuan, China.

Xueru Liu *Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.

Jianhong LiKey Laboratory of Medical Electrophysiology of the Ministry of Education, and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, Sichuan, China.

Yangpeng LiKey Laboratory of Medical Electrophysiology of the Ministry of Education, and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, Sichuan, China.

Tangting ChenKey Laboratory of Medical Electrophysiology of the Ministry of Education, and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, Sichuan, China. ctt@swmu.edu.cn.

Shuzhi ZhouDepartment of Anesthesiology, Ya 'an People's Hospital, Ya 'an, 625000, Sichuan, China. shuzhi0607@163.com.

Funding

the Science and Technology Department of Sichuan Province 2022YFS0632the Science and Technology Department of Sichuan Province 2023YFS0143

6 · The paper itself

Abstract

Dexmedetomidine (DEX) is commonly used in clinical practice because of its sedative, analgesic, antisympathetic, hemodynamic stabilization and antianxiety effects. Previous clinical studies have demonstrated that DEX plays a role in both the prevention and treatment of perioperative arrhythmias. However, the precise mechanisms underlying the effects of DEX remain unclear. Furthermore, few studies have examined the effect of DEX on cardiac electrophysiology. ECG recording was performed in vivo and ex vivo on C57 mice. Simultaneous recording of membrane voltage (Vm) and [Ca

Indexed as

Action PotentialsArrhythmias, CardiacDexmedetomidineIsoproterenolAnimalsAnti-Arrhythmia AgentsCalciumElectrocardiographyMaleMiceMice, Inbred C57BLTachycardia, VentricularVentricular FibrillationAnti-Arrhythmia AgentsCalciumDexmedetomidineIsoproterenolCalcium transientCalcium transient alternationDexmedetomidineOptical mappingStressVentricular arrhythmia

Identifiers

PMID39562591

DOI10.1038/s41598-024-79236-y

PMCPMC11576759

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.