ArticlePediatrics2024
Accuracy of Screening Tests for the Diagnosis of Urinary Tract Infections in Young Children.
Article in Pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Urinary tract infections in children.Nature reviews. Urology · 2026Review
- Urinalysis Accuracy for Diagnosis of Bacteremic Urinary Tract Infections in 0-3-Month-Old Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Reevaluating the Balance Between Overtreatment and Misdiagnosis.Pediatrics · 2025Article
- Comparison of Urine Dipstick and Urine Sediment Microscopy With Culture for Diagnosing Pediatric Urinary Tract Infections: A Retrospective Cross-Sectional Study at Tikur Anbessa Hospital, Ethiopia.International journal of pediatrics · 2025Article
- Reexamining the Role of Pyuria in UTI Diagnosis.Pediatrics · 2024Article
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17 authors.
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Abstract
backgroundThe objective of this study was to compare the accuracy of available tests for pyuria, including newer automated tests, and to examine the implications of requiring them for the diagnosis of urinary tract infections (UTIs).
methodsWe included children between 1 and 36 months of age undergoing bladder catheterization for suspected UTIs who presented to 1 of 3 pediatric centers. Using a positive urine culture result as the reference standard, we compared the sensitivity of 5 modalities for assessing pyuria at the cutoffs most often used clinically for detecting children with a positive culture result: leukocyte esterase on a dipstick, white blood cell (WBC) count on manual microscopy with and without using a hemocytometer, automated WBC enumeration using flow cytometry, and automated WBC enumeration using digital imaging with particle recognition.
resultsA total of 4188 children were included. Among febrile children, the sensitivity of the 2 most widely available modalities, the leukocyte esterase test and WBC enumeration using digital imaging, had sensitivity values of 84% (95% confidence interval, 0.80-0.87) and 75% (95% confidence interval, 0.66-0.83), respectively.
conclusionsOur findings suggest that for febrile children <36 months of age undergoing bladder catheterization for suspected UTI, pyuria will be absent in ∼20% of children who are eventually shown to have pure growth of a pathogen on a culture. This raises questions about the appropriateness of requiring pyuria for the diagnosis of UTIs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.