Evidence map›Paper›PMID 39563935›Full record

ArticleFrontiers in physiology2024

Long-term hypoxia modulates depolarization activation of BK

Nikitha Nelapudi, Madison Boskind, Xiang-Qun Hu, David Mallari, Michelle Chan, Devin Wilson, Monica Romero, Eris Albert-Minckler, Lubo Zhang, Arlin B Blood and 3 more

Abstract read
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nikitha NelapudiLawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Madison BoskindLawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Xiang-Qun HuLawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
David MallariLawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Michelle ChanLawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Devin WilsonLawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Monica RomeroAdvanced Imaging and Microscopy Core, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Eris Albert-MincklerAdvanced Imaging and Microscopy Core, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Lubo ZhangLawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Arlin B BloodLawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Christopher G WilsonLawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Jose Luis PuglisiDepartment of Biostatistics, California Northstate University School of Medicine, Elk Grove, CA, United States.
Sean M WilsonLawrence D Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.

Funding

Mechanisms of uterine artery hemodynamics adaptation to pregnancy and gestational hypoxiaR01HL169157 · NHLBI · LOMA LINDA UNIVERSITY · PI Arlin B Blood, Lubo Zhang · 2023 to 2026
$3.2M
Mechanisms of newborn pulmonary hypertension caused by chronic intrauterine hypoxiaR01HL155295 · NHLBI · LOMA LINDA UNIVERSITY · PI BLOOD, ARLIN B, WILSON, SEAN M · 2022 to 2025
$3.1M
Gestational Hypoxia and Programming of Maternal, Fetal and Newborn Vascular FunctionR01HL149608 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J., WILSON, SEAN M · 2020 to 2023
$3.1M
NHLBI NIH HHS R01 HL149608NHLBI NIH HHS R01 HL155295NHLBI NIH HHS R01 HL169157
6 · The paper itself

Abstract

Introduction: Previous evidence indicates that gestational hypoxia disrupts cerebrovascular development, increasing the risk of intracranial hemorrhage and stroke in the newborn. Due to the role of cytosolic Ca Methods: Confocal imaging of cytosolic Ca Results: Membrane depolarization increased Ry-sensitive Ca Discussion: Overall, LTH attenuates Ca

Indexed as

Ca2+ oscillationCa2+ sparkscalciumhigh altitudehypoxiaion channelsmooth muscle

Identifiers

PMID39563935
PMCPMC11573761

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.