Evidence map›Paper›PMID 39565307›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Chenjun Mu, Pan Liu, Liang Liu, Yaqing Wang, Kefu Liu, Xiangyu Li, Guozhong Li, Jianbo Cheng, Mengyao Bu, Han Chen and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. KCTD Family: Emerging Regulators of GPCR Biased Signaling.Handbook of experimental pharmacology · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Chenjun Mu *Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Pan Liu *Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Liang Liu *Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.ORCID 0009-0005-0162-1241
Yaqing Wang *State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0003-0872-8189
Kefu LiuCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Xiangyu LiCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.ORCID 0000-0003-1258-8131
Guozhong LiCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Jianbo ChengCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Mengyao BuCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Han ChenCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Manpei TangCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Yuanhang YaoCenter for Life Sciences, Institute of Molecular Medicine, School of Future Technology, Peking University, Beijing 100871, China.
Jun GuanCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Tiantian MaState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, China.
Zhengrong ZhouDepartment of Basic Medical Sciences, Neuroscience Center, Shantou University Medical College, Shantou, Guangdong 515041, China.
Qingfeng WuState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, China.
Jiada LiCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Hui GuoCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Kun XiaCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.
Zhengmao HuCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.ORCID 0000-0002-3921-8205
Xiaoqing PengCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.ORCID 0000-0002-4099-5183
Bing LangDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Faxiang LiCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.ORCID 0000-0002-6442-9063
Xiao-Wei ChenCenter for Life Sciences, Institute of Molecular Medicine, School of Future Technology, Peking University, Beijing 100871, China.ORCID 0000-0001-6466-6248
Zhiheng XuState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-4809-2851
Ling YuanCenter for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.ORCID 0000-0001-7351-5097

Funding

HSTD | Natural Science Foundation of Hunan Province () 2021JJ20075MOST | National Natural Science Foundation of China (NSFC) 32070980MOST | National Natural Science Foundation of China (NSFC) 32271026MOST | National Natural Science Foundation of China (NSFC) 32330038MOST | National Natural Science Foundation of China (NSFC) 32394030MOST | National Natural Science Foundation of China (NSFC) 81901168
6 · The paper itself

Abstract

KCTD10, a member of the potassium channel tetramerization domain (KCTD) family, is implicated in neuropsychiatric disorders and functions as a substrate recognition component within the RING-type ubiquitin ligase complex. A rare de novo variant of KCTD10, p.C124W, was identified in schizophrenia cases, yet its underlying pathogenesis remains unexplored. Here, we demonstrate that heterozygous KCTD10 C124W mice display pronounced synaptic abnormalities and exhibit schizophrenia-like behaviors. Mechanistically, we reveal that KCTD10 undergoes liquid-liquid phase separation (LLPS), a process orchestrated by its intrinsically disordered region (IDR). p.C124W mutation disrupts this LLPS capability, leading to diminished degradation of RHOB and subsequent excessive accumulation in the postsynaptic density fractions. Notably, neither IDR deletion nor p.C124W mutation in KCTD10 mitigates the synaptic abnormalities caused by

Indexed as

SchizophreniaSynapsesAnimalsHumansMiceMutationPotassium Channels, Voltage-GatedKCTD10 protein, humanPotassium Channels, Voltage-GatedKCTD10liquid–liquid phase separation (LLPS)neuropsychiatric disordersynaptic abnormalities

Identifiers

PMID39565307
PMCPMC11621769

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.