Evidence map›Paper›PMID 39565347›Full record

ArticleeLife2024

Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis.

Clément Mazeaud, Stefan Pfister, Jonathan E Owen, Higor Sette Pereira, Flavie Charbonneau, Zachary E Robinson, Anaïs Anton, Cheyanne L Bemis, Aïssatou Aïcha Sow, Trushar R Patel and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Clément MazeaudCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Canada.ORCID https://orcid.org/0009-0003-0152-4615
Stefan PfisterLeibniz Institute of Virology, Hamburg, Germany.
Jonathan E OwenDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, United States.
Higor Sette PereiraDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, Canada.ORCID https://orcid.org/0000-0003-4761-8361
Flavie CharbonneauCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Canada.
Zachary E RobinsonDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, Canada.
Anaïs AntonCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Canada.
Cheyanne L BemisDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, United States.
Aïssatou Aïcha SowCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Canada.
Trushar R PatelDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, Canada.ORCID https://orcid.org/0000-0003-0627-2923
Christopher J NeufeldtDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, United States.ORCID https://orcid.org/0000-0002-4551-1811
Pietro ScaturroLeibniz Institute of Virology, Hamburg, Germany.
Laurent Chatel-ChaixCentre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Canada.ORCID https://orcid.org/0000-0002-7390-8250

Funding

Host factor contribution to positive-strand RNA virus induced membrane reorganizationR01AI185849 · NIAID · EMORY UNIVERSITY · PI Christopher Neufeldt · 2024 to 2026
$1.5M
Armand-Frappier Foundation PhD fellowshipBundesministerium für Bildung und Forschung VirMScanCanada Foundation for Innovation CFI-37155Canada Foundation for Innovation CFI-41008Center of Excellence in Research on Orphan Diseases - Fondation Courtois PhD fellowshipDeutsche Forschungsgemeinschaft SC 314/1-2Fonds de recherche du Québec - Nature et technologies 2018-NC-205593Fonds de recherche du Québec - Nature et technologies PhD fellowshipNatural Sciences and Engineering Research Council of Canada CREATE postdoctoral fellowship awardNatural Sciences and Engineering Research Council of Canada RGPIN-2016-05584Natural Sciences and Engineering Research Council of Canada RGPIN-2022-03391NIAID NIH HHS R01 AI185849
6 · The paper itself

Abstract

Zika virus (ZIKV) infection causes significant human disease that, with no approved treatment or vaccine, constitutes a major public health concern. Its life cycle entirely relies on the cytoplasmic fate of the viral RNA genome (vRNA) through a fine-tuned equilibrium between vRNA translation, replication, and packaging into new virions, all within virus-induced replication organelles (vROs). In this study, with an RNA interference (RNAi) mini-screening and subsequent functional characterization, we have identified insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) as a new host dependency factor that regulates vRNA synthesis. In infected cells, IGF2BP2 associates with viral NS5 polymerase and redistributes to the perinuclear viral replication compartment. Combined fluorescence

Indexed as

RNA-Binding ProteinsVirus ReplicationZika VirusAnimalsHost-Pathogen InteractionsHumansRibonucleoproteinsRNA, ViralViral Replication CompartmentsZika Virus InfectionIGF2BP2 protein, humanRibonucleoproteinsRNA-Binding ProteinsRNA, Viralcell biologyigf2bp2IGF2BP2infectious diseasemicrobiologyRNA-binding proteinsviral replication organelleviral rnazika virusZika virus

Identifiers

PMID39565347
PMCPMC11578589

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.