Evidence map›Paper›PMID 39567619›Full record

SynthesisScientific reports2024

A systematic review and meta-analysis of blood level of MCP-1/CCL-2 in severe and uncomplicated malaria.

Manas Kotepui, Pattamaporn Kwankaew, Aongart Mahittikorn, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Apichai Wattanapisit, Polrat Wilairatana

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manas KotepuiMedical Technology Program, Faculty of Science, Nakhon Phanom University, Nakhon Phanom, Thailand. manaskote@gmail.com.
Pattamaporn KwankaewMedical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.
Aongart MahittikornDepartment of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand. aongart.mah@mahidol.ac.th.
Kwuntida Uthaisar KotepuiMedical Technology Program, Faculty of Science, Nakhon Phanom University, Nakhon Phanom, Thailand.
Frederick Ramirez MasangkayDepartment of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila, 1008, Philippines.
Apichai WattanapisitSchool of Medicine, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.
Polrat WilairatanaDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monocyte chemoattractant protein-1 (MCP-1) or C-C Motif Chemokine Ligand 2 (CCL-2) is a key chemokine implicated in the inflammatory response to malaria. The objective of the study was to synthesize the evidence on variations in MCP-1/CCL-2 levels in relation to Plasmodium spp. infections and the severity of malaria. The protocol for this systematic review and meta-analysis was registered at PROSPERO (CRD42024565867). To identify relevant studies, a comprehensive search strategy was conducted using major databases, including PubMed, Scopus, Embase, Medline, Journals@Ovid, and Nursing & Allied Health Premium. The Joanna Briggs Institute (JBI) critical appraisal checklists were used to determine the risk of bias in selected studies. The pooled standardized mean difference (SMD, Hedge's g) and their 95% confidence interval (CI) were estimated using the random-effects model. Thirty-three studies, with a total of 6,804 participants enrolled, were included in the systematic review. Most studies (60.6%) were published between 2010 and 2019; the majority (57.6%) were conducted in Africa. The predominant Plasmodium species studied was P. falciparum (66.7%). The meta-analysis revealed no significant difference in MCP-1/CCL-2 levels between Plasmodium-infected and uninfected individuals (P: 0.16, SMD: 0.99, 95% CI: -0.39-2.37, I

Indexed as

Chemokine CCL2MalariaBiomarkersHumansMalaria, FalciparumPlasmodium falciparumSeverity of Illness IndexBiomarkersCCL2 protein, humanChemokine CCL2CCL-2MalariaMCP-1Meta-analysisPlasmodiumSystematic review

Identifiers

PMID39567619
PMCPMC11579328

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.