Evidence map›Paper›PMID 39567890›Full record

SynthesisBMC cardiovascular disorders2024

Sex hormones and reproductive factors with cardiac arrhythmia and ECG indices: a mendelian randomization study.

Xishu Wang, Zhaoyang Wei, Zheng Zuo, Ying Sun, Xiaoxue Guo, Yi Tong, Guanghui Liu, Dongyang Xu, Zhiguo Zhang

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xishu WangCardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, No.1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Zhaoyang WeiCardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, No.1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Zheng ZuoCardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, No.1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Ying SunCardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, No.1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Xiaoxue GuoCardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, No.1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Yi TongCardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, No.1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Guanghui LiuCardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, No.1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Dongyang XuCardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, No.1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Zhiguo ZhangCardiovascular Medicine Department, Cardiology Center, First Hospital of Jilin University, No.1 Xinmin Street, Changchun City, 130021, Jilin Province, China. zhangzhig@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSex is a determinant of the incidence and etiology of arrhythmia. Observational and basic studies suggest that sex hormones are essential in this process; however, the relationship between sex hormones and arrhythmia remains unclear. Mendelian randomization (MR) was used to investigate the causal relationships between sex hormone levels, arrhythmia, and electrocardiographic (ECG) indices.

methodsLarge genome-wide association studies (GWAS) data on sex hormones, stratified by sex, from the UK biobank consortium, were used as exposure data, and data on atrial fibrillation (AF), atrioventricular block, sick sinus syndrome, paroxysmal tachycardia, and ECG indices were obtained from the FinnGen consortium and summarized large GWAS data. Inverse variance weighting or wald odds was used as the primary analytical method, and weighted medians and MR-Egger regression were used for complementary analyses. The results of the MR of sex hormones and AF from different sources were analyzed using a meta-analysis. Summary-data-based MR analysis was utilized to explore the relationship between sex-hormone related drugs and arrhythmia.

resultsIn men, genetically predicted higher estradiol concentrations were associated with a lower risk of AF (odds ratio: 0.908 [0.852-0.967]; p = 0.0029], whereas genetically predicted higher concentrations of total testosterone were associated with lower heart rate variability. Sex hormones showed no association with atrioventricular block, sick sinus syndrome, paroxysmal tachycardia, resting heart rate, P wave duration, P wave terminal force in lead V1 [PTFV1], PR interval, QRS duration, QTc [QT interval corrected by heart rate], ST duration, spatial [spQRSTa] and frontal [fQRSTa] QRS-T angles in males. In females, there was no significant evidence that sex hormones are associated with arrhythmias or ECG indices.

conclusionIn this study, we identified a potential causal relationship between estradiol and the risk of AF in males. However, there was no significant association between sex hormones and either arrhythmias or ECG indices in females. These results suggested that sex hormones may play a limited role in cardiac arrhythmias, which requires further verification.

Indexed as

Arrhythmias, CardiacElectrocardiographyGenome-Wide Association StudyHeart RateMendelian Randomization AnalysisAction PotentialsEstradiolFemaleGonadal Steroid HormonesHumansMaleMiddle AgedPhenotypePolymorphism, Single NucleotideProtective FactorsRisk AssessmentEstradiolGonadal Steroid HormonesArrhythmiaElectrocardiographyMendelian randomizationReproductive factorsSex hormones

Identifiers

PMID39567890
PMCPMC11577811

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.