Evidence map›Paper›PMID 39568070›Full record

ArticleMolecular neurodegeneration2024

Regulation of disease-associated microglia in the optic nerve by lipoxin B

Shubham Maurya, Maggie Lin, Shruthi Karnam, Tanirika Singh, Matangi Kumar, Emily Ward, Jeremy Sivak, John G Flanagan, Karsten Gronert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurodegeneration, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Neuroinflammation in glaucoma: a myriad of cellular pathways and players.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  2. Review
  3. Article
  4. Microglial polarization in retinal neovascularization: Friend or foe?Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Lipoxin BbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Shubham MauryaHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, USA.
Maggie LinHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, USA.
Shruthi KarnamHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, USA.
Tanirika SinghHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, USA.
Matangi KumarHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, USA.
Emily WardHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, USA.
Jeremy SivakDonald K Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
John G FlanaganHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, USA.
Karsten GronertHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, USA. kgronert@berkeley.edu.ORCID 0000-0002-5329-7907

Funding

UC Berkeley Vision Science COREP30EY003176 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI KARSTEN GRONERT · 1985 to 2026
$16.4M
TRAINING PROGRAM IN VISION SCIENCET32EY007043 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Suzanne MJ FLEISZIG · 1985 to 2026
$12.9M
Homeostatic Role and Therapeutic Potential of the Neuroprotective Retinal Lipoxin CircuitR01EY030218 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLANAGAN, JOHN G, GRONERT, KARSTEN · 2020 to 2024
$2.4M
BrightFocus Foundation G2023001FGlaucoma Research Foundation Glaucoma Research FoundationNEI NIH HHS P30 EY003176NEI NIH HHS P30EY003176NEI NIH HHS R01 EY030218NEI NIH HHS R01EY030218NEI NIH HHS T32 EY007043
6 · The paper itself

Abstract

backgroundThe resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocular hypertension-induced neuropathy. Lipoxin B

methodsCellular targets and signaling of LXB

resultsSingle-cell transcriptomics identified microglia as a primary target for LXB

conclusionWe identified early and dynamic changes in the microglia functional phenotype, reactivity, and induction of a unique CD74 microglia population in the distal optic nerve as key features of ocular hypertension-induced neurodegeneration. Our findings establish microglia regulation as a novel LXB

Indexed as

MicrogliaOcular HypertensionOptic NerveRetinal Ganglion CellsAnimalsDisease Models, AnimalLipoxinsMiceMice, Inbred C57BLRetinaLipoxinsGlaucomaLipoxinsMicroglia reactivityNeurodegenerationOptic nerveRetina

Identifiers

PMID39568070
PMCPMC11580672

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.