ArticleeLife2024
ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis.
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In one paragraph
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Non-receptor tyrosine kinase signaling pathways and therapeutic implications.Signal transduction and targeted therapy · 2026Review
- Human iPSC-derived alveolar macrophages reveal macrophage subtype functions of itaconate in M. tuberculosis defense.JCI insight · 2026Article
- High-dimensional phenotyping reveals novel macrophage-like and hybrid subsets within murine splenic conventional dendritic cells.PloS one · 2026Article
- Application potential of induced pluripotent stem cells in the research and treatment of autoimmune diseases (Review).Molecular medicine reports · 2025Review
- Genetic Spectrum of Negative Electroretinograms in a Predominantly Pediatric Cohort of 177 Patients.Investigative ophthalmology & visual science · 2025Article
- Characterization of the mammalian prodefinitive angio-hematopoietic lineage.Science immunology · 2025Article
Corrections and comments
- Update of
Authors and funding
25 authors.
Stephanie Guillet *Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0002-9038-6765
Tomi Lazarov *Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0002-6312-0080
Natasha JordanCentre for Molecular and Cellular Biology of Inflammation (CMCBI), King's College London and Louise Coote Lupus Unit, Guy's and Thomas' Hospitals, London, United Kingdom.
Bertrand BoissonSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, United States.
Maria TelloImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0001-8909-6800
Barbara CraddockSKI Stem Cell Research Core, Memorial Sloan Kettering Cancer Center, New York, United States.
Ting ZhouSKI Stem Cell Research Core, Memorial Sloan Kettering Cancer Center, New York, United States.
Chihiro NishiLaboratory of Biochemistry & Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Rohan BarejaCary and Israel Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Meyer Cancer Center Weill Cornell Medical College, New York, United States.
Hairu YangImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.
Frederic Rieux-LaucatUniversity of Paris Cité, Imagine Institute, Paris, France.
Rosa Irene Fregel LorenzoUniversity of La Laguna, San Cristóbal de La Laguna, Spain.
Sabrina D DyallDepartment of Biosciences and Ocean Studies, Faculty of Science, University of Mauritius, Reduit, Mauritius.
David IsenbergBioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, United States.
David D'CruzCentre for Molecular and Cellular Biology of Inflammation (CMCBI), King's College London and Louise Coote Lupus Unit, Guy's and Thomas' Hospitals, London, United Kingdom.
Nico LachmannCentre for Rheumatology, Division of Medicine, University College London, The Rayne Building, London, United Kingdom.
Olivier ElementoCary and Israel Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Meyer Cancer Center Weill Cornell Medical College, New York, United States.
Agnes VialeInstitute of Experimental Hematology, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany.
Nicholas D SocciInstitute of Experimental Hematology, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany.
Laurent AbelSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, United States.
Shigekazu NagataLaboratory of Biochemistry & Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-9758-8426
Morgan HuseImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.
W Todd Miller *Marie-Josée & Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, United States.
Jean-Laurent Casanova *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, United States.
Frédéric GeissmannImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0001-5029-2468
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MHuman genetics of TB resistance in HIV-infected personsR01AI124349 · NIAID · MCGILL UNIVERSITY HEALTH CTR RES INST · PI SCHURR, ERWIN · 2016 to 2020
$8.0MSynaptic Control of Cytotoxic T cell FunctionR01AI087644 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HUSE, MORGAN A · 2010 to 2025
$7.3MMacrophage development and specification in mice.R01AI130345 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Frederic Geissmann · 2017 to 2026
$5.7MSUSTRATE SPECIFICITY OF NONRECEPTOR TYROSINE KINASER01CA058530 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI MILLER, W TODD · 1999 to 2018
$3.7MNonreceptor tyrosine kinases in Systemic Lupus ErythematosusR01AI164424 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MILLER, W TODD · 2021 to 2025
$1.6MSUBSTRATE SPECIFICITY OF NONRECEPTOR TYROSINE KINASESR29CA058530 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI MILLER, W TODD · 1993 to 1997
–Arthritis Research UK FellowshipAssistance Publique - Hôpitaux de Paris Annee RechercheCore Research for Evolutional Science and Technology JPMJCR14M4Fondation pour la Recherche Médicale DEA20140630127Grants-in-Aid for Scientific Research No. 15H05785National Institute of Allergy and Infectious Diseases 1R01AI130345-01National Institute of Allergy and Infectious Diseases 5R01AI124349-03National Institute of Allergy and Infectious Diseases R01-AI087644NCI NIH HHS CA58530NCI NIH HHS P30 CA008748NCI NIH HHS P30CA008748NCI NIH HHS R01 CA058530NIAID NIH HHS R01 AI087644NIAID NIH HHS R01 AI124349NIAID NIH HHS R01 AI130345NIAID NIH HHS R01 AI164424
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease, the pathophysiology and genetic basis of which are incompletely understood. Using a forward genetic screen in multiplex families with SLE, we identified an association between SLE and compound heterozygous deleterious variants in the non-receptor tyrosine kinases (NRTKs)
Indexed as
Lupus Erythematosus, SystemicMacrophagesPhagocytosisAdultAnimalsAutoantibodiesc-Mer Tyrosine KinaseDisease Models, AnimalEfferocytosisFemaleHumansMaleMiceProtein-Tyrosine KinasesAutoantibodiesc-Mer Tyrosine KinaseProtein-Tyrosine KinasesACK1BRKgenetic diseasesgeneticsgenomicshumanimmunologyinflammationmousesystemic lupus
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.