Evidence map›Paper›PMID 39571369›Full record

ArticleAmerican journal of surgery2025

Balancing risks of surgical complications and positive margins for patients with invasive lobular carcinoma of the breast and elevated BMI: An institutional cohort study.

Israel Falade, Kayla Switalla, Astrid Quirarte, Molly Baxter, Daniel Soroudi, Harriet Rothschild, Shoko Emily Abe, Karen Goodwin, Merisa Piper, Michael Alvarado and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Israel FaladeUniversity of California San Francisco, School of Medicine, San Francisco, CA, USA. Electronic address: israel.falade@ucsf.edu.
Kayla SwitallaUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Astrid QuirarteUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Molly BaxterUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Daniel SoroudiUniversity of California San Francisco, School of Medicine, San Francisco, CA, USA.
Harriet RothschildUniversity of California San Francisco, School of Medicine, San Francisco, CA, USA.
Shoko Emily AbeUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Karen GoodwinUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Merisa PiperUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Michael AlvaradoUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Bao-Quynh JulianUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Cheryl EwingUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Jasmine WongUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
John RoseUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Laura EssermanUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Robert FosterUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.
Rita A MukhtarUniversity of California San Francisco, Department of Surgery, San Francisco, CA, USA.

Funding

Identifying responders to chemotherapy in invasive lobular carcinoma of the breast: development of a multivariable clinical prediction toolK08CA256047 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MUKHTAR, RITA · 2021 to 2025
$1.3M
NCI NIH HHS K08 CA256047
6 · The paper itself

Abstract

backgroundThe risks of postoperative complications in breast cancer patients vary by patient and tumor characteristics. Elevated BMI and invasive lobular carcinoma (ILC) increase risks of surgical complications and positive margins, respectively.

methodsWe retrospectively analyzed patients with BMI ≥30 ​kg/m

resultsOf 154 analyzed patients, standard BCS, lumpectomy with oncoplastic closure, and simple mastectomy had the lowest complication rates (18.2 ​%, 17.0 ​%, 11.8 ​%). Oncoplastic reduction mammoplasty and mastectomy with aesthetic closure had the highest rates (35.5 ​%, 33.3 ​%). The overall positive margin rate was 28.5 ​%, significantly higher in BCS vs. mastectomy (37.4 ​% vs. 15.0 ​%, p ​= ​0.003). Oncoplastic surgery significantly reduced positive margin rates in BCS.

conclusionIn this study, 23.4 ​% of patients experienced surgical complications, with higher rates in oncoplastic/reconstructive approaches. However, oncoplastic surgery reduced positive margins, highlighting the importance of balancing risks for optimal surgical planning.

Indexed as

Body Mass IndexBreast NeoplasmsCarcinoma, LobularMargins of ExcisionMastectomyPostoperative ComplicationsAdultAgedFemaleHumansMammaplastyMastectomy, SegmentalMiddle AgedNeoplasm InvasivenessRetrospective Studies

Identifiers

PMID39571369
PMCPMC12212894

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.