Evidence map›Paper›PMID 39571568›Full record

ArticleKidney & blood pressure research2024

Renal and Vascular Functional Decline in Aged Low Birth Weight Murine Adults.

May M Rabadi, Marella R Verde, Mia Camilliere, Nicholas Vecchio, Sharath Kandhi, Miroslav Sekulic, Michael S Wolin, Brian B Ratliff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney & blood pressure research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cocoa Shell Extract Restores Redox Balance in Developmental Hypertension in Male Rats: Roles of Nrf2, SOD2 and p-eNOS.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

May M RabadiDepartment of Medicine, New York Medical College, Valhalla, New York, USA.
Marella R VerdeDepartment of Physiology, New York Medical College, Valhalla, New York, USA.
Mia CamilliereDepartment of Pathology, New York Medical College, Valhalla, New York, USA.
Nicholas VecchioDepartment of Medicine, New York Medical College, Valhalla, New York, USA.
Sharath KandhiDepartment of Physiology, New York Medical College, Valhalla, New York, USA.
Miroslav SekulicDepartment of Pathology and Cell Biology, College of Physicians and Surgeons of Columbia University, New York, New York, USA.
Michael S WolinDepartment of Physiology, New York Medical College, Valhalla, New York, USA.
Brian B RatliffDepartment of Medicine, New York Medical College, Valhalla, New York, USA.

Funding

NOX4-associated oxidative stress mediates vascular and kidney impairment in the low birth weight adultR01HL151187 · NHLBI · NEW YORK MEDICAL COLLEGE · PI RATLIFF, BRIAN BLAKE, WOLIN, MICHAEL S · 2020 to 2023
$1.6M
NHLBI NIH HHS R01 HL151187
6 · The paper itself

Abstract

introductionMaternal undernutrition (MUN)-induced low birth weight (LBW) neonates are susceptible to the development of high blood pressure and kidney disease later in life, although the underlying pathological causes remain unclear. The study here investigated the role of renal oxidative stress, impairment of vascular function, and altered sensitivity to angiotensin II (Ang II) as factors that contribute to these pathologies in aged LBW mice.

methodsLBW offspring were generated using a combined protein and caloric restricted MUN mouse model. The resulting LBW offspring were examined 1 year after birth for mean arterial blood pressure (MABP) (carotid artery catheterization), renal blood flow (RBF) (laser Doppler flowmetry), glomerular filtration rate (GFR) (sinistrin clearance), vasoreactivity (myograph), renal vascular density (CD31 staining), and reactive oxygen species (ROS) (ROS probes). Immunoblotting examined Ang II type 1 receptor (AT1R), soluble guanylate cyclase (sGC), and antioxidant systems. Pharmacological agents delivered to animals included the sGC stimulator δ-aminolevulinic acid (ALA), the AT1R inhibitor losartan, the antioxidant ethyl pyruvate (EP), and the toll-like receptor 4 inhibitor TAK242.

resultsAfter 1 year, MABP was increased, while RBF, GFR, vascular reactivity, renal vascular density, and sGC were all reduced in the LBW aged adult. All four pharmacological agents improved MABP, RBF, GFR, vascular density, and vascular reactivity. Renal ROS was increased in the LBW adult but was reduced by ALA, EP, and TAK242 treatment. AT1R was upregulated in the LBW adult, while sGC was decreased, an effect reversed by ALA treatment. Endogenous antioxidant systems, including SOD1, catalase, and glutathione were downregulated in the LBW adult.

conclusionMUN-induced LBW mice experience increased Ang II sensitivity and oxidative stress. The increased Ang II sensitivity and ROS generation influences vascular density and reactivity, which drive an increase in MABP, and a concomitantly decrease in RBF and glomerular filtration. Pharmacological intervention that inhibits AT1R, enhances levels of sGC, reduces ROS, or inhibits toll-like receptor 4 improves vascular and renal function in the LBW adult.

Indexed as

Oxidative StressAgingAngiotensin IIAnimalsBlood PressureFemaleGlomerular Filtration RateKidneyMiceReactive Oxygen SpeciesRenal CirculationAngiotensin IIReactive Oxygen SpeciesAngiotensin IILow birth weightMaternal undernutrition mouse modelOxidative stressRenal insufficiencyVascular impairment

Identifiers

PMID39571568
PMCPMC11652227

What Socratic holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.