Evidence map›Paper›PMID 39572432›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Presynaptic terminal integrity is associated with glucose metabolism in Parkinson's disease.

Weiyi Wang, Yanru Wang, Limin Xu, Xueling Liu, Yuqing Hu, Junpeng Li, Qi Huang, Shuhua Ren, Yiyun Huang, Yihui Guan and 4 more

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Weiyi Wang *Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yanru Wang *Department of Nuclear Medicine, Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China.
Limin Xu *Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China.
Xueling LiuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Yuqing HuDepartment of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China.
Junpeng LiDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Qi HuangDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Shuhua RenDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yiyun HuangPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA.
Yihui GuanDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yuxin LiDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Fengchun HuaDepartment of Nuclear Medicine, Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China. huafc@hotmail.com.
Qing YeDepartment of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China. yeqing1982889@163.com.
Fang XieDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China. fangxie@fudan.edu.cn.ORCID 0000-0003-2667-281X

Funding

Clinical Research Plan of SHDC No. SHDC2020CR2056BNational Major Science and Technology Projects of China 2022ZD0213800the National Science Foundation of China 81801752the National Science Foundation of China 82071962the National Science Foundation of China 82171473the National Science Foundation of China 82201583the Shanghai Municipal Key Clinical Specialty 3030247006the Shanghai Municipal Science and Technology Major Project No. 2018SHZDZX01the Shanghai Sailing Program 18YF1403200the Shanghai Sailing Program 19YF1405300the startup fund of Huashan Hospital, Fudan University 2017QD081
6 · The paper itself

Abstract

objectiveTo investigate the relationship of synaptic loss with glucose metabolism and dopaminergic transporters in Parkinson's disease (PD) patients.

methodsA total of 16 patients with PD and 11 age-matched healthy controls underwent positron emission tomography (PET) with the tracers [

resultsCompared with that in the NC group, the synaptic density in the caudate region was significantly lower in the PD group (SUVR: 2.51 ± 0.36 vs. 3.18 ± 0.32, p < 0.001), especially in the pre-commissural caudate and post-commissural caudate (SUVR: 2.42 ± 0.29 vs. 2.63 ± 0.32, p < 0.01; 0.76 ± 0.31 vs. 0.97 ± 0.33, p < 0.001). A reduced synaptic density was significantly correlated with DAT (r = 0.61, p < 0.001) and glucose metabolism (r = 0.73, p < 0.001) in the post-commissural caudate. In the post-commissural regions of the caudate, there was a partial mediating effect of synaptic density on the relationship between glucose metabolism and DAT availability (indirect effect: β

conclusion[

Indexed as

GlucoseParkinson DiseasePresynaptic TerminalsAgedCase-Control StudiesDopamine Plasma Membrane Transport ProteinsFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPositron-Emission TomographyTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneDopamine Plasma Membrane Transport ProteinsFluorodeoxyglucose F18GlucoseTropanesDopaminergic transporterGlucose metabolismParkinson’s diseaseSynaptic vesicle protein 2A

Identifiers

PMID39572432

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.