Evidence map›Paper›PMID 39572547›Full record

ArticleNature communications2024

Astrocytic inhibition of lateral septal neurons promotes diverse stress responses.

Kain Seo, Sanghyun Won, Hee-Yoon Lee, Yeonju Sin, Sangho Lee, Hyejin Park, Yong Geon Kim, Seo Young Yang, Dong-Jae Kim, Kyoungho Suk and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Astrocytes in Rodent Anxiety-Related Behavior: Role of Calcium and Beyond.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kain Seo *Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.
Sanghyun Won *Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.ORCID 0009-0005-7668-5477
Hee-Yoon Lee *Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
Yeonju SinDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.ORCID 0000-0003-2090-9900
Sangho LeeDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.
Hyejin ParkLaboratory Animal Resource Center, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.
Yong Geon KimDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.
Seo Young YangDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.
Dong-Jae KimLaboratory Animal Resource Center, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.
Kyoungho SukDepartment of Pharmacology, School of Medicine, Brain Science and Engineering Institute, Kyungpook National University, Daegu, Republic of Korea.ORCID 0000-0002-9555-4203
Ja Wook KooEmotion, Cognition and Behavior Research Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.ORCID 0000-0001-6233-1583
Myungin BaekDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.ORCID 0000-0001-8906-901X
Se-Young ChoiDepartment of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea. sychoi@snu.ac.kr.ORCID 0000-0001-7534-5167
Hyosang LeeDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea. hyosang22@dgist.ac.kr.

Funding

National Research Foundation of Korea (NRF) 2020R1A2C3011464National Research Foundation of Korea (NRF) 2020R1A6A1A03040516National Research Foundation of Korea (NRF) RS-2024-00354104
6 · The paper itself

Abstract

Inhibitory neuronal circuits within the lateral septum (LS) play a key role in regulating mood and stress responses. Even though glial cells can modulate these circuits, the impact of astrocytes on LS neural circuits and their functional interactions remains largely unexplored. Here, we demonstrate that astrocytes exhibit increased intracellular Ca²⁺ levels in response to aversive sensory and social stimuli in both male and female mice. This astrocytic Ca²⁺ elevation inhibits neighboring LS neurons by reducing excitatory synaptic transmissions through A

Indexed as

AstrocytesNeuronsStress, PsychologicalAnimalsAnxietyCalciumCorticosteroneFemaleHeart RateMaleMiceMice, Inbred C57BLSeptal NucleiSynaptic TransmissionCalciumCorticosterone

Identifiers

PMID39572547
PMCPMC11582824

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.