Evidence map›Paper›PMID 39572891›Full record

ArticleFEBS open bio2025

Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes.

Kazuya Kusama, Kodai Oka, Yumi Yashiro, Kanoko Yoshida, Hiroaki Miyaoka, Kazuhiro Tamura

Abstract read
In one paragraph

Article in FEBS open bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Nutrients · 2026
    Article
  2. Effect ofInternational journal of endocrinology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kazuya KusamaDepartment of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.ORCID https://orcid.org/0000-0002-9120-0475
Kodai OkaDepartment of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.
Yumi YashiroDepartment of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.
Kanoko YoshidaDepartment of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.ORCID https://orcid.org/0000-0001-8720-9568
Hiroaki MiyaokaDepartment of Biomolecular Organic Chemistry, Tokyo University of Pharmacy and Life Sciences, Japan.ORCID https://orcid.org/0000-0003-2486-0403
Kazuhiro TamuraDepartment of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan.ORCID https://orcid.org/0000-0003-3351-895X

Funding

Ministry of Economy, Trade and Industry, Japan
6 · The paper itself

Abstract

Obesity, a global health concern, results from an energy imbalance leading to lipid accumulation. In the present study, Cordyceps militaris extract (CM) and its primary component, cordycepin, were investigated to characterize their potential effects on adipogenesis and lipolysis. Treatment with CM or cordycepin reduced lipid droplets and increased hormone-sensitive lipase activation in 3T3-L1 cells. In a diabetic obese mouse model, CM and cordycepin lowered serum low-density lipoprotein/very low-density lipoprotein levels and reduced oxidative stress and cell senescence markers. Thus, cordycepin inhibits preadipocyte differentiation and promotes lipolysis, which may serve as a novel obesity treatment. Further studies, including clinical trials, are required to validate the clinical potential of cordycepin.

Indexed as

AdipocytesAdipogenesisCordycepsDeoxyadenosinesLipolysisPlant Extracts3T3-L1 CellsAnimalsCell DifferentiationMaleMiceMice, Inbred C57BLObesityOxidative StresscordycepinDeoxyadenosinesPlant Extractsadipocytecell senescencecordycepinCordyceps militarisoxidative stress

Identifiers

PMID39572891
PMCPMC11788751

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.