Evidence map›Paper›PMID 39574071›Full record

ArticleBMC oral health2024

Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis.

Yurika Ninomiya, Shinji Matsuda, Shigeki Suzuki, Shizu Hirata-Tsuchiya, Tomoya Ueda, Fuminori Nakashima, Keisuke Yasuda, Shogo Shimada, Takumi Memida, Tetsuya Yoshimoto and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yurika Ninomiya *Department of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Shinji Matsuda *Department of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan. matsudas@hiroshima-u.ac.jp.
Shigeki SuzukiDepartment of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Shizu Hirata-TsuchiyaDepartment of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Tomoya UedaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Fuminori NakashimaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Keisuke YasudaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Shogo ShimadaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Takumi MemidaDepartment of Oral Science and Translation Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, USA.
Tetsuya YoshimotoCenter of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan.
Satoru YamadaDepartment of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Kazuhisa OuharaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Noriyoshi MizunoDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.

Funding

Japan Science and Technology Corporation JPMJSP2132Japan Society for the Promotion of Science 20K18536
6 · The paper itself

Abstract

backgroundThis study aimed to elucidate the pathogenesis of idiopathic gingival fibromatosis (IGF).

methodsHuman gingival fibroblasts (hGFs) were isolated from patients with IGF and periodontitis. Differential gene expression in the hGFs was analyzed using RNA sequencing. Extracellular matrix-related gene expression in the hGFs was analyzed. The effect of specific protein (SP)1 inhibitor or recombinant human transglutaminase 2 (rh-TGM2) on biglycan (BGN) expression in hGFs was also determined.

resultsRNA sequencing showed that TGM2 expression was downregulated and BGN mRNA expression was upregulated in patients with IGF relative to periodontitis. rh-TGM2 stimulation of hGFs in patients with IGF significantly reduced BGN expression. SP1 inhibitors downregulated BGN expression in the hGFs.

conclusionBGN upregulation via SP1 causes TGM2 downregulation in gingival fibroblasts in IGF.

Indexed as

BiglycanFibroblastsFibromatosis, GingivalGTP-Binding ProteinsProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesAdultCells, CulturedDown-RegulationGingivaHumansSp1 Transcription FactorBiglycanGTP-Binding ProteinsProtein Glutamine gamma Glutamyltransferase 2Sp1 Transcription FactorTGM2 protein, humanTransglutaminasesBiglycanHuman gingival fibroblastIdiopathic gingival fibromatosisPeriodontitisSpecific protein 1Transglutaminase 2

Identifiers

PMID39574071
PMCPMC11583685

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.