Evidence map›Paper›PMID 39574073›Full record

Observational studyBMC pediatrics2024

Clinical features and risk factors for development of post-infectious bronchiolitis obliterans in children.

Weihan Xu, Xiaohui Wen, Haiming Yang, Jinrong Liu, Xiaolei Tang, Hui Xu, Hui Liu, Huimin Li, Shunying Zhao

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weihan XuDepartment of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, NO.56, Nanlishi Road, Beijing, 100045, P. R. China.
Xiaohui WenDepartment of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, NO.56, Nanlishi Road, Beijing, 100045, P. R. China.
Haiming YangDepartment of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, NO.56, Nanlishi Road, Beijing, 100045, P. R. China.
Jinrong LiuDepartment of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, NO.56, Nanlishi Road, Beijing, 100045, P. R. China.
Xiaolei TangDepartment of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, NO.56, Nanlishi Road, Beijing, 100045, P. R. China.
Hui XuDepartment of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, NO.56, Nanlishi Road, Beijing, 100045, P. R. China.
Hui LiuDepartment of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, NO.56, Nanlishi Road, Beijing, 100045, P. R. China.
Huimin LiDepartment of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, NO.56, Nanlishi Road, Beijing, 100045, P. R. China.
Shunying ZhaoDepartment of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, NO.56, Nanlishi Road, Beijing, 100045, P. R. China. zhaoshunying2001@163.com.

Funding

Respiratory Research Project of National Clinical Research Center for Respiratory Diseases No. HX2X-202103
6 · The paper itself

Abstract

backgroundPost-infectious bronchiolitis obliterans (PIBO) is a severe form of chronic obstructive lung disease secondary to severe respiratory tract infections. Knowledge of pediatric PIBO development-associated risk factors may improve selection of appropriate early therapeutic interventions.

objectiveThe aim of this study was to describe the clinical characteristics of children diagnosed with PIBO, and identify the risk factors for development of PIBO after adenovirus pneumonia.

methodsFirst, a retrospective observational study was performed of 308 pediatric patients with PIBO (ages < 5 years) that revealed high frequencies of non-invasive/invasive ventilation, co-infection, and atopic conditions. Subsequently, we retrospectively reviewed 131 patients (ages < 5 years) with adenovirus pneumonia who developed BO (included among the 308 children) or not. Logistic regression analysis revealed PIBO development-associated risk factors.

resultsRespiratory symptoms of 308 patients (median age of 18 months, range: 12-54 months; male predominance of 3.7:1) included wheezing (71%), dyspnea (66%), tachypnea (23%), and hypoxemia (18%). Etiologic agents (predominantly adenovirus, Mycoplasma pneumoniae) were detected in 236 patients, of whom 137 had co-infections. Notably, atopic disease history (of patients and/or family members) was associated with 78% of patients, and 15% of patients diagnosed with asthma before, at the time of PIBO diagnosis. In a subsequent study of 131 adenovirus pneumonia patients, multivariate analysis showed that co-infection (OR 4.20, 95% CI 1.29 to 13.63), atopic conditions (OR 29.67, 95% CI 12.16 to 81.67), and duration of fever (OR 1.42, 95% CI 1.10 to 1.83) were independent risk factors for PIBO development following adenovirus pneumonia.

conclusionsAtopic conditions, co-infections, and duration of fever were identified as risk factors for pediatric post-infectious BO development following adenovirus pneumonia, and PIBO may overlap with asthma, warranting early aggressive treatment and further research to elucidate roles of atopic conditions in BO development.

Indexed as

Bronchiolitis ObliteransAdenovirus Infections, HumanChild, PreschoolCoinfectionFemaleHumansInfantMalePneumonia, MycoplasmaRetrospective StudiesRisk FactorsAdenovirusAsthmaAtopicBronchiolitis obliteransChildrenCo-infection

Identifiers

PMID39574073
PMCPMC11580501

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.